4IUM

Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin

Summary for 4IUM

Descriptorpapain-like protease 2, Ubiquitin, ZINC ION, ... (5 entities in total)
Functional Keywordsviral ovarian tumor domain (otu) protease, deubiquitinase, hydrolase-protein binding complex, hydrolase/protein binding
Biological sourceEquine arteritis virus (EAV)
More
Cellular locationNsp1 papain-like cysteine proteinase: Host nucleus. Nsp2 cysteine proteinase: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 5-6-7: Host membrane; Multi-pass membrane protein (Potential). 3C-like serine proteinase: Host cytoplasm (Potential). RNA-directed RNA polymerase: Host cytoplasm, host perinuclear region (Potential). Helicase: Host cytoplasm, host perinuclear region (Potential) P19811
Ubiquitin: Cytoplasm (By similarity) P0CG48
Total number of polymer chains2
Total molecular weight24044.8
Authors
Bailey-Elkin, B.A.,James, T.W.,Mark, B.L. (deposition date: 2013-01-21, release date: 2013-02-13, Last modification date: 2013-03-20)
Primary citation
van Kasteren, P.B.,Bailey-Elkin, B.A.,James, T.W.,Ninaber, D.K.,Beugeling, C.,Khajehpour, M.,Snijder, E.J.,Mark, B.L.,Kikkert, M.
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Proc.Natl.Acad.Sci.USA, 110:E838-E847, 2013
PubMed: 23401522 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1218464110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.45 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1764000.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report