Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6DTE

GlcNAc-inspired cyclophellitol bound to NagZ

Summary for 6DTE
Entry DOI10.2210/pdb6dte/pdb
DescriptorBeta-hexosaminidase, 2,2,2-trifluoro-N-[(1R,2R,3R,4R,5R,6R)-2,3,5,6-tetrahydroxy-4-(hydroxymethyl)cyclohexyl]acetamide (3 entities in total)
Functional Keywordsantibiotic potentiator, antibiotic adjuvant, nagz, glycosides, epoxide, glcnac, antibiotic resistance, ampc, hydrolase
Biological sourceBurkholderia cenocepacia
Total number of polymer chains2
Total formula weight76811.94
Authors
Mark, B.L.,Winogrodzki, J.L. (deposition date: 2018-06-15, release date: 2019-04-24, Last modification date: 2023-10-11)
Primary citationHo, L.A.,Winogrodzki, J.L.,Debowski, A.W.,Madden, Z.,Vocadlo, D.J.,Mark, B.L.,Stubbs, K.A.
A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa.
Chem. Commun. (Camb.), 54:10630-10633, 2018
Cited by
PubMed: 30178799
DOI: 10.1039/c8cc05281f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.929 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon