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6DG5
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STRUCTURE OF A DE NOVO DESIGNED INTERLEUKIN-2/INTERLEUKIN-15 MIMETIC COMPLEX WITH IL-2RB AND IL-2RG
Descriptor:Neoleukin-2/15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ...
Authors:Jude, K.M., Silva, D.-A., Yu, S., Baker, D., Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
6DG6
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STRUCTURE OF A DE NOVO DESIGNED INTERLEUKIN-2/INTERLEUKIN-15 MIMETIC
Descriptor:Neoleukin-2/15
Authors:Jude, K.M., Silva, D.-A., Yu, S., Baker, D., Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
6E5C
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SOLUTION NMR STRUCTURE OF A DE NOVO DESIGNED DOUBLE-STRANDED BETA-HELIX
Descriptor:De novo beta protein
Authors:Marcos, E., Chidyausiku, T.M., McShan, A., Evangelidis, T., Nerli, S., Sgourakis, N., Tripsianes, K., Baker, D.
Deposit date:2018-07-19
Release date:2018-11-07
Last modified:2018-11-14
Method:SOLUTION NMR
Cite:De novo design of a non-local beta-sheet protein with high stability and accuracy.
Nat. Struct. Mol. Biol., 25, 2018
6CZG
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STRUCTURE OF A REDESIGNED BETA BARREL, B11L5F_LGL
Descriptor:b11L5F_LGL
Authors:Doyle, L.A., Stoddard, B.L.
Deposit date:2018-04-09
Release date:2018-09-19
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
6CZH
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STRUCTURE OF A REDESIGNED BETA BARREL, MFAP0, BOUND TO DFHBI
Descriptor:mFAP0, (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one
Authors:Doyle, L.A., Stoddard, B.L.
Deposit date:2018-04-09
Release date:2018-09-19
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
6CZI
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STRUCTURE OF A REDESIGNED BETA BARREL, MFAP1, BOUND TO DFHBI
Descriptor:mFAP1, (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one
Authors:Doyle, L.A., Stoddard, B.L.
Deposit date:2018-04-09
Release date:2018-09-19
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
6CZJ
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STRUCTURE OF A REDESIGNED BETA BARREL, B10
Descriptor:b10, SULFATE ION
Authors:Doyle, L.A., Stoddard, B.L.
Deposit date:2018-04-09
Release date:2018-09-19
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
6D0T
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DE NOVO DESIGN OF A FLUORESCENCE-ACTIVATING BETA BARREL - BB1
Descriptor:BB1
Authors:Dou, J., Vorobieva, A.A., Sheffler, W., Doyle, L.A., Park, H., Bick, M.J., Mao, B., Foight, G.W., Lee, M., Carter, L., Sankaran, B., Ovchinnikov, S., Marcos, E., Huang, P., Vaughan, J.C., Stoddard, B.L., Baker, D.
Deposit date:2018-04-10
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
5L33
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN WITH CURVED BETA-SHEET
Descriptor:denovo NTF2
Authors:Oberdorfer, G., Marcos, E., Basanta, B., Chidyausiku, T.M., Sankaran, B., Baker, D.
Deposit date:2016-08-03
Release date:2017-01-25
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5TPH
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN HOMODIMER WITH CURVED BETA-SHEET
Descriptor:de novo NTF2 homodimer, DI(HYDROXYETHYL)ETHER, CHLORIDE ION
Authors:Basanta, B., Marcos, E., Oberdorfer, G., Chidyausiku, T.M., Sankaran, B., Baker, D.
Deposit date:2016-10-20
Release date:2017-01-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5TPJ
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN WITH CURVED BETA-SHEET
Descriptor:denovo NTF2
Authors:Basanta, B., Oberdorfer, G., Marcos, E., Chidyausiku, T.M., Sankaran, B., Baker, D.
Deposit date:2016-10-20
Release date:2017-01-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5TRV
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN WITH CURVED BETA-SHEET
Descriptor:denovo NTF2, DI(HYDROXYETHYL)ETHER
Authors:Basanta, B., Oberdorfer, G., Marcos, E., Chidyausiku, T.M., Sankaran, B., Baker, D.
Deposit date:2016-10-27
Release date:2017-01-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5TS4
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN WITH CURVED BETA-SHEET
Descriptor:denovo NTF2, DI(HYDROXYETHYL)ETHER
Authors:Basanta, B., Oberdorfer, G., Chidyausiku, T.M., Marcos, E., Pereira, J.H., Sankaran, B., Zwart, P.H., Baker, D.
Deposit date:2016-10-27
Release date:2017-01-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5U35
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN WITH CURVED BETA-SHEET
Descriptor:De novo NTF2 with large cavity, 2-METHOXYETHANOL, CHLORIDE ION, ...
Authors:Oberdorfer, G., Marcos, E., Basanta, B., Chidyausiku, T.M., Sankaran, B., Zwart, P.H., Baker, D.
Deposit date:2016-12-01
Release date:2017-01-25
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5KPH
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SOLUTION NMR STRUCTURE OF DENOVO BETA SHEET DESIGN PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR485
Descriptor:De novo Beta Sheet Design Protein OR485
Authors:Tang, Y., Liu, G., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-07-04
Release date:2016-09-28
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5KPE
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SOLUTION NMR STRUCTURE OF DENOVO BETA SHEET DESIGN PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR664
Descriptor:De novo Beta Sheet Design Protein OR664
Authors:Tang, Y., Liu, G., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-07-03
Release date:2016-09-21
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
4R80
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CRYSTAL STRUCTURE OF A DE NOVO DESIGNED BETA SHEET PROTEIN, CYSTATIN FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR486
Descriptor:OR486
Authors:Guan, R., Marcos, E., O'Connell, P., Seetharaman, J., Janjua, H., Xiao, R., Maglaqui, M., Acton, T.B., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-08-29
Release date:2014-09-24
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:Crystal Structure of an engineered protein with denovo beta sheet design, Northeast Structural Genomics Consortium (NESG) Target OR486
To be Published