2KDI
| Solution structure of a Ubiquitin/UIM fusion protein | Descriptor: | Ubiquitin, Vacuolar protein sorting-associated protein 27 fusion protein | Authors: | Sgourakis, N.G, Patel, M.M, Garcia, A.E, Makhatadze, G.I, McCallum, S.A. | Deposit date: | 2009-01-09 | Release date: | 2010-02-09 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Conformational Dynamics and Structural Plasticity Play Critical Roles in the Ubiquitin Recognition of a UIM Domain. J.Mol.Biol., 396, 2010
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3J1X
| A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly | Descriptor: | Protein PrgH | Authors: | Sgourakis, N.G, Bergeron, J.R.C, Worrall, L.J, Strynadka, N.C.J, Baker, D. | Deposit date: | 2012-07-10 | Release date: | 2013-05-22 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (11.7 Å) | Cite: | A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly. Plos Pathog., 9, 2013
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3J1V
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3J1W
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2MPZ
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2MIZ
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6OSW
| An order-to-disorder structural switch activates the FoxM1 transcription factor | Descriptor: | Forkhead box M1 | Authors: | Marceau, A.H, Rubin, S.M, Nerli, S, McShane, A.C, Sgourakis, N.G. | Deposit date: | 2019-05-02 | Release date: | 2019-05-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | An order-to-disorder structural switch activates the FoxM1 transcription factor. Elife, 8, 2019
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5WOT
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5WOY
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7RNO
| Model of the Ac-6-FP/hpMR1/bB2m/TAPBPR complex from integrated docking, NMR and restrained MD | Descriptor: | Beta-2-microglobulin, Major histocompatibility complex class I-related gene protein, N-(6-formyl-4-oxo-3,4-dihydropteridin-2-yl)acetamide, ... | Authors: | McShan, A.C, Sgourakis, N.G. | Deposit date: | 2021-07-29 | Release date: | 2022-05-11 | Last modified: | 2022-08-10 | Method: | SOLUTION NMR | Cite: | TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nat.Chem.Biol., 18, 2022
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8EK5
| Engineered scFv 10LH bound to PHOX2B/HLA-A24:02 | Descriptor: | 10LH single chain fragment variable (scFv), Beta-2-microglobulin, GLYCEROL, ... | Authors: | Garfinkle, S.E, Florio, T.J, Sgourakis, N.G. | Deposit date: | 2022-09-20 | Release date: | 2023-12-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
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8SBK
| Structure of HLA-A*24:02 in complex with peptide, LYLPVRVLI (ATG2A). | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, LEU-TYR-LEU-PRO-VAL-ARG-VAL-LEU-ILE, ... | Authors: | Mallik, L, Young, M.C, Sgourakis, N.G. | Deposit date: | 2023-04-03 | Release date: | 2023-12-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
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8SBL
| Structure of HLA-A*24:02 in complex with peptide, LYLPVRVLI | Descriptor: | Beta-2-microglobulin, LEU-TYR-LEU-PRO-VAL-ARG-VAL-LEU-ILE, MHC class I antigen | Authors: | Mallik, L, Young, M.C, Sgourakis, N.G. | Deposit date: | 2023-04-03 | Release date: | 2023-12-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
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6MPP
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8ERX
| Structure of chimeric HLA-A*11:01-A*02:01 bound to HIV-1 RT peptide | Descriptor: | Beta-2-microglobulin, HIV-1 RT, HLA-A*02:01 | Authors: | Florio, T.J, Ani, O, Young, M.C, Mallik, L, Sgourakis, N.G. | Deposit date: | 2022-10-13 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Front Immunol, 14, 2023
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8ESH
| Structure of chimeric HLA-A*02:01 bound to CMV peptide | Descriptor: | Beta-2-microglobulin, CMV peptide, HLA-A*02:01 | Authors: | Florio, T.J, Ani, O, Young, M.C, Mallik, L, Sgourakis, N.G. | Deposit date: | 2022-10-14 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Front Immunol, 14, 2023
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6B9K
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6AT9
| Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-A*0101 | Descriptor: | ALK, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Toor, J, Rao, A.A, Salama, S, Tripathi, S, Haussler, D, Sgourakis, N.G. | Deposit date: | 2017-08-28 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9503 Å) | Cite: | A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9, 2018
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7RY6
| Solution NMR structural bundle of the first cyclization domain from yersiniabactin synthetase (Cy1) impacted by dynamics | Descriptor: | HMWP2 nonribosomal peptide synthetase | Authors: | Kancherla, A.K, Mishra, S.H, Marincin, K.A, Nerli, S, Sgourakis, N.G, Dowling, D.P, Bouvignies, G, Frueh, D.P. | Deposit date: | 2021-08-24 | Release date: | 2022-07-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Global protein dynamics as communication sensors in peptide synthetase domains. Sci Adv, 8, 2022
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6E5C
| Solution NMR structure of a de novo designed double-stranded beta-helix | Descriptor: | De novo beta protein | Authors: | Marcos, E, Chidyausiku, T.M, McShan, A, Evangelidis, T, Nerli, S, Sgourakis, N, Tripsianes, K, Baker, D. | Deposit date: | 2018-07-19 | Release date: | 2018-11-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | De novo design of a non-local beta-sheet protein with high stability and accuracy. Nat. Struct. Mol. Biol., 25, 2018
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5VZ5
| Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501 | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Toor, J, Rao, A.A, Salama, S, Tripathi, S, Haussler, D, Sgourakis, N.G. | Deposit date: | 2017-05-26 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5901 Å) | Cite: | A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9, 2018
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5TXS
| Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-15 alpha chain, ... | Authors: | Toor, J, Rao, A.A, Salama, S, Tripathi, S, Haussler, D, Sgourakis, N.G. | Deposit date: | 2016-11-17 | Release date: | 2017-11-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.697 Å) | Cite: | A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9, 2018
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5WOX
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5WOZ
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6O0I
| NMR ensemble of computationally designed protein XAA | Descriptor: | Design construct XAA | Authors: | Wei, K.Y, Moschidi, D, Nerli, S, Sgourakis, N, Baker, D. | Deposit date: | 2019-02-16 | Release date: | 2020-04-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proc.Natl.Acad.Sci.USA, 117, 2020
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