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4HA7
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STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7
Descriptor:2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Authors:Lv, Z., Sun, J., Liu, Y.
Deposit date:2012-09-25
Release date:2013-09-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional insights into Saccharomyces cerevisiae riboflavin biosynthesis reductase RIB7.
Plos One, 8, 2013
4HA9
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STRUCTURAL INSIGHTS INTO THE REDUCTION MECHANISM OF SACCHAROMYCES CEREVISIA RIBOFLAVIN BIOSYNTHESIS REDUCTASE RIB7
Descriptor:2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Lv, Z., Sun, J., Liu, Y.
Deposit date:2012-09-25
Release date:2013-09-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and functional insights into Saccharomyces cerevisiae riboflavin biosynthesis reductase RIB7.
Plos One, 8, 2013
5UM6
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CRYSTAL STRUCTURE OF S. POMBE UBA1 IN A CLOSED CONFORMATION
Descriptor:Ubiquitin-activating enzyme E1 1, SULFATE ION, N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine, ...
Authors:Lv, Z., Yuan, L., Aldana-Masangkay, G., Atkison, J.H., Chen, Y., Olsen, S.K.
Deposit date:2017-01-26
Release date:2017-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
J. Biol. Chem., 292, 2017
6CWY
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CRYSTAL STRUCTURE OF SUMO E1 IN COMPLEX WITH AN ALLOSTERIC INHIBITOR
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ...
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.462 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6CWZ
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CRYSTAL STRUCTURE OF APO SUMO E1
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ZINC ION
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6DC6
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CRYSTAL STRUCTURE OF HUMAN UBIQUITIN ACTIVATING ENZYME E1 (UBA1) IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin-like modifier-activating enzyme 1, Ubiquitin, MAGNESIUM ION, ...
Authors:Lv, Z., Yuan, L., Williams, K.M., Atkison, J.H., Olsen, S.K.
Deposit date:2018-05-04
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.
J. Biol. Chem., 293, 2018
5JHH
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN THE HUMAN RHOA, ITS INHIBITOR AND THE DH/PH DOMAIN OF HUMAN ARHGEF11
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL, ...
Authors:Lv, Z., Wang, R., Ma, L., Miao, Q., Wu, J., Yan, Z., Li, J., Miao, L., Wang, F.
Deposit date:2016-04-21
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF
To Be Published
5KNL
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CRYSTAL STRUCTURE OF S. POMBE UBIQUITIN E1 (UBA1) IN COMPLEX WITH UBC15 AND UBIQUITIN
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin, Ubiquitin-conjugating enzyme E2 15, ...
Authors:Olsen, S.K., Lv, Z., Yuan, L., Williams, K.
Deposit date:2016-06-28
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Mol. Cell, 65, 2017
3UA3
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CRYSTAL STRUCTURE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT5 IN COMPLEX WITH SAH
Descriptor:Protein arginine N-methyltransferase 5, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Sun, L., Wang, M., Lv, Z., Yang, N., Liu, Y., Bao, S., Gong, W., Xu, R.M.
Deposit date:2011-10-20
Release date:2011-12-14
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
3UA4
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CRYSTAL STRUCTURE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT5
Descriptor:Protein arginine N-methyltransferase 5, GLYCEROL
Authors:Sun, L., Wang, M., Lv, Z., Yang, N., Liu, Y., Bao, S., Gong, W., Xu, R.M.
Deposit date:2011-10-21
Release date:2011-12-14
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
4J0U
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CRYSTAL STRUCTURE OF IFIT5/ISG58
Descriptor:Interferon-induced protein with tetratricopeptide repeats 5
Authors:Liu, Y., Liang, H., Feng, F., Yuan, L., Wang, Y.E., Crowley, C., Lv, Z., Li, J., Zeng, S., Cheng, G.
Deposit date:2013-01-31
Release date:2013-02-13
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Crystal Structure of IFIT5
To be Published
5GT9
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THE X-RAY STRUCTURE OF 7BETA-HYDROXYSTEROID DEHYDROGENASE
Descriptor:Oxidoreductase, short chain dehydrogenase/reductase family protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wang, F., Wang, R., Lv, Z., Chen, Q., Huo, X.
Deposit date:2016-08-19
Release date:2017-05-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of NADP(+)-bound 7 beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes
Acta Crystallogr F Struct Biol Commun, 73, 2017
5TTE
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CRYSTAL STRUCTURE OF AN RBR E3 UBIQUITIN LIGASE IN COMPLEX WITH AN E2-UB THIOESTER INTERMEDIATE MIMIC
Descriptor:E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ubiquitin, ...
Authors:Yuan, L., Lv, Z., Olsen, S.K.
Deposit date:2016-11-03
Release date:2017-08-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.
Nat Commun, 8, 2017
5TUB
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CRYSTAL STRUCTURE OF THE SHARK TBC1D15 GAP DOMAIN
Descriptor:Shark TBC1D15 GTPase-activating Protein
Authors:Chen, Y.-N., Wang, W., Cheng, D., Ge, Y., Gu, X., Zhou, X.E., Ye, F., Xu, H.E., Lv, Z.
Deposit date:2016-11-05
Release date:2017-02-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
5TUC
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CRYSTAL STRUCTURE OF THE SUS TBC1D15 GAP DOMAIN
Descriptor:Sus TBC1D15 GAP Domain
Authors:Chen, Y.-N., Wang, W., Cheng, D., Ge, Y., Gu, X., Zhou, X.E., Ye, F., Xu, H.E., Lv, Z.
Deposit date:2016-11-05
Release date:2017-02-22
Last modified:2017-04-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
3EBJ
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CRYSTAL STRUCTURE OF AN AVIAN INFLUENZA VIRUS PROTEIN
Descriptor:Polymerase acidic protein, MAGNESIUM ION
Authors:Yuan, P., Bartlam, M., Lou, Z., Chen, S., Rao, Z., Liu, Y.
Deposit date:2008-08-27
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
Nature, 458, 2009
5JHG
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE HUMAN RHOA AND THE DH/PH DOMAIN OF HUMAN ARHGEF11
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL
Authors:Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.
Deposit date:2016-04-21
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published