5JHH

Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11

Summary for 5JHH

• Entry DOI: 10.2210/pdb5jhh/pdb
• Related: 5JHG
• Descriptor: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL, ... (5 entities in total)
• Functional Keywords: rhoa-inhibitor-arhgef11 ternary complex, target-based pharmaceutical design, signaling protein-transcription-inhibitor complex, signaling protein/transcription/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : O15085; Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
• Total number of polymer chains: 4
• Total formula weight: 127667.28

Authors

Lv, Z.,Wang, R.,Ma, L.,Miao, Q.,Wu, J.,Yan, Z.,Li, J.,Miao, L.,Wang, F. (deposition date: 2016-04-21, release date: 2017-04-26, Last modification date: 2024-03-20)

• Primary citation: Wang, R.,Yan, Z.,Lv, Z.,Ma, L.,Miao, Q.,Chen, Q.,Wang, F.,Li, J.,Miao, L.; Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)