5JHH
Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11
Summary for 5JHH
Entry DOI | 10.2210/pdb5jhh/pdb |
Related | 5JHG |
Descriptor | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL, ... (5 entities in total) |
Functional Keywords | rhoa-inhibitor-arhgef11 ternary complex, target-based pharmaceutical design, signaling protein-transcription-inhibitor complex, signaling protein/transcription/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : O15085 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586 |
Total number of polymer chains | 4 |
Total formula weight | 127667.28 |
Authors | |
Primary citation | Wang, R.,Yan, Z.,Lv, Z.,Ma, L.,Miao, Q.,Chen, Q.,Wang, F.,Li, J.,Miao, L. Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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