7LFV

Crystal structure of the SARS CoV-1 Papain-like protease in complex with peptide inhibitor VIR251

Summary for 7LFV

Entry DOI	10.2210/pdb7lfv/pdb
Related PRD ID	PRD_002390
Descriptor	papain-like protease, Papain-like protease peptide inhibitor VIR251, ZINC ION, ... (8 entities in total)
Functional Keywords	covid-19, coronavirus, sars, cov-1, cov-2, papain-like protease, plpro, deubiquitinating enzyme, ubiquitin, activity-based probe, hydrolase-hydrolas inhibitor complex, hydrolase/hydrolas inhibitor
Biological source	Severe acute respiratory syndrome coronavirus (SARS-CoV) More
Total number of polymer chains	4
Total formula weight	76112.03
Authors	Olsen, S.K.,Lv, Z. (deposition date: 2021-01-18, release date: 2021-11-10, Last modification date: 2023-11-15)
Primary citation	Patchett, S.,Lv, Z.,Rut, W.,Bekes, M.,Drag, M.,Olsen, S.K.,Huang, T.T. A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep, 36:109754-109754, 2021 Cited by PubMed: 34547223 DOI: 10.1016/j.celrep.2021.109754 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.23 Å)

Structure validation