7LFV
Crystal structure of the SARS CoV-1 Papain-like protease in complex with peptide inhibitor VIR251
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | papain-like protease | polymer | 325 | 36688.5 | 2 | UniProt (P0C6U8) Pfam (PF08715) UniProt (by SIFTS) (P0C6X7) | Severe acute respiratory syndrome coronavirus (SARS-CoV) | pp1a,ORF1a polyprotein |
| 2 | C, D (D, F) | Papain-like protease peptide inhibitor VIR251 | polymer | 5 | 479.5 | 2 | BIRD (PRD_002390) | synthetic construct | |
| 3 | E, U (B, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | AA, BA, CA, F, G... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 21 | Chemie (EDO) | |||
| 5 | EA, R, S (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | DA (A) | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 7 | FA (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | GA, HA, IA (B, A, F) | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
B, A: 2 - 317 (UniProt: P0C6U8)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Leu 318 | - | expression tag |
| Glu 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
| His 325 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74336.1 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 1775.9 | |
| All* | Total formula weight | 76112.0 |
