7SOL

Crystal Structures of the bispecific ubiquitin/FAT10 activating enzyme, Uba6

Summary for 7SOL

• Entry DOI: 10.2210/pdb7sol/pdb
• Descriptor: Ubiquitin-like modifier-activating enzyme 6, Ubiquitin, INOSITOL HEXAKISPHOSPHATE, ... (5 entities in total)
• Functional Keywords: ubiquitin, e1, adenylation, thioester bond, e2, fat10, ip6, ligase, atp-binding, nucleotide binding, conformational change, signaling protein, signaling protein-ligase complex, signaling protein/ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 250260.69

Authors

Olsen, S.K.,Gao, F.,Lv, Z. (deposition date: 2021-10-31, release date: 2022-11-02, Last modification date: 2024-04-17)

• Primary citation: Yuan, L.,Gao, F.,Lv, Z.,Nayak, D.,Nayak, A.,Santos Bury, P.D.,Cano, K.E.,Jia, L.,Oleinik, N.,Atilgan, F.C.,Ogretmen, B.,Williams, K.M.,Davies, C.,El Oualid, F.,Wasmuth, E.V.,Olsen, S.K.; Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.; Nat Commun, 13:4880-4880, 2022; PubMed: 35986001; DOI: 10.1038/s41467-022-32613-5

Experimental method

X-RAY DIFFRACTION (2.25000635563 Å)