7SOL

Crystal Structures of the bispecific ubiquitin/FAT10 activating enzyme, Uba6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004792	molecular_function	thiosulfate sulfurtransferase activity
A	0004839	molecular_function	ubiquitin activating enzyme activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007612	biological_process	learning
A	0007626	biological_process	locomotory behavior
A	0008641	molecular_function	ubiquitin-like modifier activating enzyme activity
A	0016567	biological_process	protein ubiquitination
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016874	molecular_function	ligase activity
A	0019780	molecular_function	FAT10 activating enzyme activity
A	0021764	biological_process	amygdala development
A	0021766	biological_process	hippocampus development
A	0032446	biological_process	protein modification by small protein conjugation
A	0036211	biological_process	protein modification process
A	0060996	biological_process	dendritic spine development
B	0003729	molecular_function	mRNA binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
C	0004792	molecular_function	thiosulfate sulfurtransferase activity
C	0004839	molecular_function	ubiquitin activating enzyme activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007612	biological_process	learning
C	0007626	biological_process	locomotory behavior
C	0008641	molecular_function	ubiquitin-like modifier activating enzyme activity
C	0016567	biological_process	protein ubiquitination
C	0016779	molecular_function	nucleotidyltransferase activity
C	0016874	molecular_function	ligase activity
C	0019780	molecular_function	FAT10 activating enzyme activity
C	0021764	biological_process	amygdala development
C	0021766	biological_process	hippocampus development
C	0032446	biological_process	protein modification by small protein conjugation
C	0036211	biological_process	protein modification process
C	0060996	biological_process	dendritic spine development
D	0003729	molecular_function	mRNA binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
B	ARG48
D	ARG48

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
A	ALA470
C	ASP569
B	GLY76
A	ARG508
D	GLY76
A	ASP569
C	ALA470
C	ASP497
C	ARG508
C	LYS521

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR54
C	THR54

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER301
A	SER737
C	SER301
C	SER737

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS544
C	LYS544

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8C7R4

Chain	Residue	Details
A	LYS729
C	LYS729

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