Author results

4HKF
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CRYSTAL STRUCTURE OF DANIO RERIO MEC-17 CATALYTIC DOMAIN IN COMPLEX WITH ACETYL-COA
Descriptor:Alpha-tubulin N-acetyltransferase, ACETYL COENZYME *A, SULFATE ION
Authors:Li, W., Zhong, C., Sun, B., Xu, S., Zhang, T., Ding, J.
Deposit date:2012-10-15
Release date:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of the acetyltransferase activity of MEC-17 towards alpha- tubulin
Cell Res., 22, 2012
6OLE
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (CDH1-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH AP AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLF
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (CDH1-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH AA AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLG
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX STALLED BY A DRUG-LIKE SMALL MOLECULE (CDH1_RNC WITH PP TRNA)
Descriptor:60S ribosomal protein L8, 40S ribosomal protein SA, 60S ribosomal protein L3, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLI
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STRUCTURE OF HUMAN RIBOSOME NASCENT CHAIN COMPLEX SELECTIVELY STALLED BY A DRUG-LIKE SMALL MOLECULE (USO1-RNC)
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLZ
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (PCSK9-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH PP TRNA
Descriptor:60S ribosomal protein L8, 40S ribosomal protein SA, 60S ribosomal protein L3, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OM0
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (PCSK9-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH AP AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OM7
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (PCSK9-RNC) STALLED BY A DRUG-LIKE SMALL MOLECULE WITH AA AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-18
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
1LCY
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CRYSTAL STRUCTURE OF THE MITOCHONDRIAL SERINE PROTEASE HTRA2
Descriptor:HtrA2 serine protease
Authors:Li, W., Srinivasula, S.M., Chai, J., Li, P., Wu, J.W., Zhang, Z., Alnemri, E.S., Shi, Y.
Deposit date:2002-04-07
Release date:2002-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nat.Struct.Biol., 9, 2002
6KMH
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THE CRYSTAL STRUCTURE OF CASK/MINT1 COMPLEX
Descriptor:Peripheral plasma membrane protein CASK, Amyloid-beta A4 precursor protein-binding family A member 1, IODIDE ION, ...
Authors:Li, W., Feng, W.
Deposit date:2019-07-31
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of CASK/Mint1 complex
To Be Published
6V9T
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TUDOR DOMAIN OF TDRD3 IN COMPLEX WITH A SMALL MOLECULE
Descriptor:Tudor domain-containing protein 3, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, UNKNOWN ATOM OR ION
Authors:Li, W., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-12-16
Release date:2019-12-25
Method:X-RAY DIFFRACTION (2.154 Å)
Cite:Tudor domain of TDRD3 in complex with a small molecule
To Be Published
3J9Z
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ACTIVATION OF GTP HYDROLYSIS IN MRNA-TRNA TRANSLOCATION BY ELONGATION FACTOR G
Descriptor:16S ribosomal RNA, P-tRNA, E-tRNA, ...
Authors:Li, W., Liu, Z., Koripella, R.K., Langlois, R., Sanyal, S., Frank, J.
Deposit date:2015-03-27
Release date:2015-07-01
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
Sci Adv, 1, 2015
3JA1
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ACTIVATION OF GTP HYDROLYSIS IN MRNA-TRNA TRANSLOCATION BY ELONGATION FACTOR G
Descriptor:30S ribosomal protein S19, 16S ribosomal RNA, mRNA, ...
Authors:Li, W., Liu, Z., Koripella, R.K., Langlois, R., Sanyal, S., Frank, J.
Deposit date:2015-03-30
Release date:2015-07-01
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
Sci Adv, 1, 2015
4V6V
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TETRACYCLINE RESISTANCE PROTEIN TET(O) BOUND TO THE RIBOSOME
Descriptor:30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:Li, W., Atkinson, G.C., Thakor, N.S., Allas, U., Lu, C., Chan, K.Y., Tenson, T., Schulten, K., Wilson, K.S., Hauryliuk, V., Frank, J.
Deposit date:2013-02-25
Release date:2014-07-09
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).
Nat Commun, 4, 2013
1H3L
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N-TERMINAL FRAGMENT OF SIGR FROM STREPTOMYCES COELICOLOR
Descriptor:RNA POLYMERASE SIGMA FACTOR
Authors:Li, W., Stevenson, C.E.M., Burton, N., Jakimowicz, P., Paget, M.S.B., Buttner, M.J., Lawson, D.M., Kleanthous, C.
Deposit date:2002-09-10
Release date:2002-10-03
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
1TB6
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2.5A CRYSTAL STRUCTURE OF THE ANTITHROMBIN-THROMBIN-HEPARIN TERNARY COMPLEX
Descriptor:thrombin, Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Li, W., Johnson, D.J., Esmon, C.T., Huntington, J.A.
Deposit date:2004-05-19
Release date:2004-08-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
Nat.Struct.Mol.Biol., 11, 2004
1ZR2
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STRUCTURE OF A SYNAPTIC GAMMA-DELTA RESOLVASE TETRAMER COVALENTLY LINKED TO TWO CLEAVED DNAS
Descriptor:TCAGTGTCCGATAATTTAT, AAA, TTATCGGACACTG, ...
Authors:Li, W., Kamtekar, S., Xiong, Y., Sarkis, G.J., Grindley, N.D., Steitz, T.A.
Deposit date:2005-05-18
Release date:2005-08-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs.
Science, 309, 2005
1ZR4
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STRUCTURE OF A SYNAPTIC GAMMA-DELTA RESOLVASE TETRAMER COVALENTLY LINKED TO TWO CLEAVED DNAS
Descriptor:TCAGTGTCCGATAATTTAT, AAA, TTATCGGACACTG, ...
Authors:Li, W., Kamtekar, S., Xiong, Y., Sarkis, G.J., Grindley, N.D., Steitz, T.A.
Deposit date:2005-05-19
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs.
Science, 309, 2005
2HI9
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CRYSTAL STRUCTURE OF HUMAN NATIVE PROTEIN C INHIBITOR
Descriptor:Plasma serine protease inhibitor, CITRIC ACID, GLYCEROL
Authors:Li, W., Adams, T.E., Huntington, J.A.
Deposit date:2006-06-29
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
2OL2
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HIGH RESOLUTION STRUCTURE OF NATIVE PCI IN SPACE GROUP P21
Descriptor:Plasma serine protease inhibitor, GLYCEROL
Authors:Li, W., Huntington, J.A.
Deposit date:2007-01-18
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
2YXQ
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THE PLUG DOMAIN OF THE SECY PROTEIN STABLIZES THE CLOSED STATE OF THE TRANSLOCATION CHANNEL AND MAINTAINS A MEMBRANE SEAL
Descriptor:Preprotein translocase subunit secY, Preprotein translocase subunit secE, Preprotein translocase secG subunit
Authors:Li, W., Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
2YXR
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THE PLUG DOMAIN OF THE SECY PROTEIN STABLIZES THE CLOSED STATE OF THE TRANSLOCATION CHANNEL AND MAINTAINS A MEMBRANE SEAL
Descriptor:Preprotein translocase subunit secY, Preprotein translocase subunit secE, Preprotein translocase secG subunit
Authors:Li, W., Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
3B9F
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1.6 A STRUCTURE OF THE PCI-THROMBIN-HEPARIN COMPLEX
Descriptor:Prothrombin, Plasma serine protease inhibitor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Li, W., Adams, T.E., Huntington, J.A.
Deposit date:2007-11-05
Release date:2008-04-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DY0
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CRYSTAL STRUCTURE OF CLEAVED PCI BOUND TO HEPARIN
Descriptor:N-terminus Plasma serine protease inhibitor, C-terminus Plasma serine protease inhibitor, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ...
Authors:Li, W., Huntington, J.A.
Deposit date:2008-07-25
Release date:2008-10-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The heparin binding site of protein C inhibitor is protease-dependent.
J.Biol.Chem., 283, 2008
3IZP
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CONFORMATION OF EF-G DURING TRANSLOCATION
Descriptor:Elongation factor G
Authors:Li, W., Trabuco, L.G., Schulten, K., Frank, J.
Deposit date:2010-11-15
Release date:2011-03-16
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY
Cite:Molecular dynamics of EF-G during translocation.
Proteins, 79, 2011
167327
數據於2020-08-05公開中