Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA

This is a large structure.

Summary for 6OLZ

EMDB information0598 0600 0599 0601 0526 0596 0597
Descriptor60S ribosomal protein L8, 40S ribosomal protein SA, 60S ribosomal protein L3, ... (85 entities in total)
Functional Keywordsselective stalling, drug-like molecule, human ribosome nascent chain complex, ribosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains82
Total molecular weight3168064.34
Li, W.,Cate, J.H.D. (deposition date: 2019-04-17, release date: 2019-06-19, Last modification date: 2019-12-18)
Primary citation
Li, W.,Ward, F.R.,McClure, K.F.,Chang, S.T.,Montabana, E.,Liras, S.,Dullea, R.G.,Cate, J.H.D.
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26:501-509, 2019
PubMed: 31160784 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-019-0236-8
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone9 0.5% 1.5% 0.39MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-08-12