Author results

4N0S
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COMPLEX OF ERK2 WITH CAFFEIC ACID
Descriptor:Mitogen-activated protein kinase 1, CAFFEIC ACID, SULFATE ION, ...
Authors:Kurinov, I., Malakhova, M.
Deposit date:2013-10-02
Release date:2014-08-27
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.7992 Å)
Cite:Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis.
Cancer Prev Res (Phila), 7, 2014
3G51
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STRUCTURAL DIVERSITY OF THE ACTIVE CONFORMATION OF THE N-TERMINAL KINASE DOMAIN OF P90 RIBOSOMAL S6 KINASE 2
Descriptor:Ribosomal protein S6 kinase alpha-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kurinov, I.
Deposit date:2009-02-04
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2
Plos One, 4, 2009
2OP2
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CRYSTAL STRUCTURE OF RNASE DOUBLE-MUTANT V43C R85C WITH EXTRA DISULPHIDE BOND
Descriptor:Ribonuclease pancreatic
Authors:Kurinov, I.
Deposit date:2007-01-26
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Implementation of a k/k(0) Method to Identify Long-Range Structure in Transition States during Conformational Folding/Unfolding of Proteins.
Structure, 15, 2007
3SA0
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COMPLEX OF ERK2 WITH NORATHYRIOL
Descriptor:Mitogen-activated protein kinase 1, norathyriol, SULFATE ION
Authors:Kurinov, I., Malakhova, M.
Deposit date:2011-06-02
Release date:2011-12-14
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.5947 Å)
Cite:Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases.
Cancer Res., 72, 2012
4ZXT
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COMPLEX OF ERK2 WITH CATECHOL
Descriptor:Mitogen-activated protein kinase 1, CATECHOL, SULFATE ION, ...
Authors:Kurinov, I., Malakhova, M.
Deposit date:2015-05-20
Release date:2016-05-25
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.
Oncotarget, 7, 2016
5WP1
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COMPLEX OF ERK2 WITH 5,7-DIHYDROXYCHROMONE
Descriptor:Mitogen-activated protein kinase 1, 5,7-dihydroxy-4H-1-benzopyran-4-one, SULFATE ION, ...
Authors:Kurinov, I., Malakhova, M.
Deposit date:2017-08-03
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Multiple phytochemicals at low doses accumulatively inhibit one key protein in cancers
To Be Published
6OCP
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CRYSTAL STRUCTURE OF A HUMAN GABAB RECEPTOR PEPTIDE BOUND TO KCTD16 T1
Descriptor:BTB/POZ domain-containing protein KCTD16, Gamma-aminobutyric acid type B receptor subunit 2
Authors:Zuo, H., Glaaser, I., Zhao, Y., Kurinov, I., Mosyak, L., Wang, H., Liu, J., Park, J., Frangaj, A., Sturchler, E., Zhou, M., McDonald, P., Geng, Y., Slesinger, P.A., Fan, Q.R.
Deposit date:2019-03-25
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OCR
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CRYSTAL STRUCTURE OF HUMAN KCTD16 T1 DOMAIN
Descriptor:BTB/POZ domain-containing protein KCTD16
Authors:Zuo, H., Glaaser, I., Zhao, Y., Kurinov, I., Mosyak, L., Wang, H., Liu, J., Park, J., Frangaj, A., Sturchler, E., Zhou, M., McDonald, P., Geng, Y., Slesinger, P.A., Fan, Q.R.
Deposit date:2019-03-25
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OCT
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CRYSTAL STRUCTURE OF HUMAN KCTD16 T1 DOMAIN
Descriptor:BTB/POZ domain-containing protein KCTD16
Authors:Zuo, H., Glaaser, I., Zhao, Y., Kurinov, I., Mosyak, L., Wang, H., Liu, J., Park, J., Frangaj, A., Sturchler, E., Zhou, M., McDonald, P., Geng, Y., Slesinger, P.A., Fan, Q.R.
Deposit date:2019-03-25
Release date:2019-04-10
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor.
Proc.Natl.Acad.Sci.USA, 116, 2019
1YMN
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THE STUDY OF REDUCTIVE UNFOLDING PATHWAYS OF RNASE A (Y92L MUTANT)
Descriptor:Ribonuclease pancreatic
Authors:Xu, G., Narayan, M., Kurinov, I., Ripoll, D.R., Welker, E., Khalili, M., Ealick, S.E., Scheraga, H.A.
Deposit date:2005-01-21
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A localized specific interaction alters the unfolding pathways of structural homologues.
J.Am.Chem.Soc., 128, 2006
1YMR
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THE STUDY OF REDUCTIVE UNFOLDING PATHWAYS OF RNASE A (Y92A MUTANT)
Descriptor:Ribonuclease pancreatic
Authors:Xu, G., Narayan, M., Kurinov, I., Ripoll, D.R., Welker, E., Khalili, M., Ealick, S.E., Scheraga, H.A.
Deposit date:2005-01-21
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A localized specific interaction alters the unfolding pathways of structural homologues.
J.Am.Chem.Soc., 128, 2006
1YMW
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THE STUDY OF REDUCTIVE UNFOLDING PATHWAYS OF RNASE A (Y92G MUTANT)
Descriptor:Ribonuclease pancreatic
Authors:Xu, G., Narayan, M., Kurinov, I., Ripoll, D.R., Welker, E., Khalili, M., Ealick, S.E., Scheraga, H.A.
Deposit date:2005-01-21
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A localized specific interaction alters the unfolding pathways of structural homologues.
J.Am.Chem.Soc., 128, 2006
3BS5
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CRYSTAL STRUCTURE OF HCNK2-SAM/DHYP-SAM COMPLEX
Descriptor:Protein aveugle, Connector enhancer of kinase suppressor of ras 2
Authors:Rajakulendran, T., Ceccarelli, D.F., Kurinov, I., Sicheri, F.
Deposit date:2007-12-22
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.
Proc.Natl.Acad.Sci.USA, 105, 2008
3HYM
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INSIGHTS INTO ANAPHASE PROMOTING COMPLEX TPR SUBDOMAIN ASSEMBLY FROM A CDC26-APC6 STRUCTURE
Descriptor:Anaphase-promoting complex subunit CDC26, Cell division cycle protein 16 homolog
Authors:Wang, J., Dye, B.T., Rajashankar, K.R., Kurinov, I., Schulman, B.A.
Deposit date:2009-06-22
Release date:2009-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.
Nat.Struct.Mol.Biol., 16, 2009
3RTR
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A RING E3-SUBSTRATE COMPLEX POISED FOR UBIQUITIN-LIKE PROTEIN TRANSFER: STRUCTURAL INSIGHTS INTO CULLIN-RING LIGASES
Descriptor:Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
Authors:Calabrese, M.F., Scott, D.C., Duda, D.M., Grace, C.R., Kurinov, I., Kriwacki, R.W., Schulman, B.A.
Deposit date:2011-05-03
Release date:2011-07-20
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
3T7E
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7F
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7G
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, Autophagy-related protein 3
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7H
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
4GSJ
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CRYSTAL STRUCTURE OF ATG7 NTD K14A F16A D18A MUTANT
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, CITRIC ACID, ISOPROPYL ALCOHOL
Authors:Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.
Deposit date:2012-08-27
Release date:2012-11-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.695 Å)
Cite:Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
Nat.Struct.Mol.Biol., 19, 2012
4GSK
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CRYSTAL STRUCTURE OF AN ATG7-ATG10 CROSSLINKED COMPLEX
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, Ubiquitin-like-conjugating enzyme ATG10, ZINC ION
Authors:Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.
Deposit date:2012-08-27
Release date:2012-11-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
Nat.Struct.Mol.Biol., 19, 2012
4GSL
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CRYSTAL STRUCTURE OF AN ATG7-ATG3 CROSSLINKED COMPLEX
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, Autophagy-related protein 3, ZINC ION
Authors:Kaiser, S.E., Mao, K., Taherbhoy, A.M., Yu, S., Olszewski, J.L., Duda, D.M., Kurinov, I., Deng, A., Fenn, T.D., Klionsky, D.J., Schulman, B.A.
Deposit date:2012-08-27
Release date:2012-11-14
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
Nat.Struct.Mol.Biol., 19, 2012
4R2Y
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CRYSTAL STRUCTURE OF APC11 RING DOMAIN
Descriptor:Anaphase-promoting complex subunit 11, ZINC ION
Authors:Brown, N.G., Watson, E.R., Weissmann, F., Jarvis, M.A., Vanderlinden, R., Grace, C.R.R., Frye, J.J., Dube, P., Qiao, R., Petzold, G., Cho, S.E., Alsharif, O., Bao, J., Zheng, J., Nourse, A., Kurinov, I., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2014-08-13
Release date:2014-10-29
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (1.755 Å)
Cite:Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly.
Mol.Cell, 56, 2014
5K5S
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CRYSTAL STRUCTURE OF THE ACTIVE FORM OF HUMAN CALCIUM-SENSING RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Extracellular calcium-sensing receptor, TRYPTOPHAN, PHOSPHATE ION, ...
Authors:Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T.C., Subramanyam, P., Brown, A.P., Brennan, S.C., Mun, H.-C., Bush, M., Chen, Y., Nguyen, T., Cao, B., Chang, D., Quick, M., Conigrave, A., Colecraft, H.M., McDonald, P., Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
5K5T
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CRYSTAL STRUCTURE OF THE INACTIVE FORM OF HUMAN CALCIUM-SENSING RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Extracellular calcium-sensing receptor, CALCIUM ION, SULFATE ION, ...
Authors:Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T.C., Subramanyam, P., Brown, A.P., Brennan, S.C., Mun, H.-C., Bush, M., Chen, Y., Nguyen, T., Cao, B., Chang, D., Quick, M., Conigrave, A., Colecraft, H.M., McDonald, P., Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016