Author results

4X2Z
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STRUCTURAL VIEW AND SUBSTRATE SPECIFICITY OF PAPAIN-LIKE PROTEASE FROM AVIAN INFECTIOUS BRONCHITIS VIRUS
Descriptor:Nonstructural protein 3, ZINC ION
Authors:Kong, L., Shaw, N., Yan, L., Lou, Z., Rao, Z.
Deposit date:2014-11-27
Release date:2015-01-28
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus.
J.Biol.Chem., 290, 2015
5CD3
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STRUCTURE OF IMMATURE VRC01-CLASS ANTIBODY DRVIA7
Descriptor:DRVIA7 Heavy Chain, DRVIA7 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-02
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5JS9
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 8-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (6.918 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JSA
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 10-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (6.308 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
4DGV
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HCV1, P2(1) FORM
Descriptor:HCV1 Heavy Chain, HCV1 Light Chain, E2 peptide, ...
Authors:Kong, L., Wilson, I.A., Law, M.
Deposit date:2012-01-26
Release date:2012-05-23
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DGY
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HCV1, C2 FORM
Descriptor:HCV1 Heavy Chain, HCV1 Light Chain, E2 peptide, ...
Authors:Kong, L., Wilson, I.A., Law, M.
Deposit date:2012-01-27
Release date:2012-05-23
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G6A
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY AP33
Descriptor:E2 peptide, AP33 Heavy Chain, AP33 Light chain
Authors:Kong, L., Wilson, I.A., Law, M.
Deposit date:2012-07-18
Release date:2012-09-26
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33.
J.Virol., 86, 2012
4JM2
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CRYSTAL STRUCTURE OF PGT 135 FAB IN COMPLEX WITH GP120 CORE PROTEIN FROM HIV-1 STRAIN JR-FL BOUND TO CD4 AND 17B FAB
Descriptor:PGT 135 Heavy chain, PGT 135 Light chain, 17b Light chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2013-03-13
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat.Struct.Mol.Biol., 20, 2013
4JM4
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CRYSTAL STRUCTURE OF PGT 135 FAB
Descriptor:PGT 135 Heavy Chain, PGT 135 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2013-03-13
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat.Struct.Mol.Biol., 20, 2013
4MWF
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3C
Descriptor:Fab AR3C heavy chain, Fab AR3C light chain, Envelope glycoprotein E2, ...
Authors:Kong, L., Wilson, I.A., Law, M.
Deposit date:2013-09-24
Release date:2013-12-11
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.645 Å)
Cite:Hepatitis C virus e2 envelope glycoprotein core structure.
Science, 342, 2013
4N0Y
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STRUCTURE OF THE HEPATITIS C ENVELOPE GLYCOPROTEIN E1 ANTIGENIC REGION 314-324 BOUND TO THE CROSS-NEUTRALIZING ANTIBODY IGH526
Descriptor:IGH526 Heavy Chain, IGH526 Light Chain, HCV E1 peptide, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2013-10-02
Release date:2015-04-01
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structure of Hepatitis C Virus Envelope Glycoprotein E1 Antigenic Site 314-324 in Complex with Antibody IGH526.
J.Mol.Biol., 427, 2015
4RQS
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CRYSTAL STRUCTURE OF FULLY GLYCOSYLATED HIV-1 GP120 CORE BOUND TO CD4 AND 17B FAB
Descriptor:2-domain CD4, 17b Fab Light Chain, 17b Fab Heavy Chain, ...
Authors:Kong, L., Wilson, I.A., Kwong, P.D.
Deposit date:2014-11-05
Release date:2014-12-31
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (4.493 Å)
Cite:Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262.
Proteins, 83, 2015
5C7K
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CRYSTAL STRUCTURE BG505 SOSIP GP140 HIV-1 ENV TRIMER BOUND TO BROADLY NEUTRALIZING ANTIBODIES PGT128 AND 8ANC195
Descriptor:Antibody Fab PGT128 heavy chain, Antibody Fab PGT128 light chain, Envelope glycoprotein gp120, ...
Authors:Kong, L., Stanfield, R.L., Wilson, I.A.
Deposit date:2015-06-24
Release date:2015-10-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (4.6019 Å)
Cite:Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.
Acta Crystallogr.,Sect.D, 71, 2015
6DLU
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CRYO-EM OF THE GMPPCP-BOUND HUMAN DYNAMIN-1 POLYMER ASSEMBLED ON THE MEMBRANE IN THE CONSTRICTED STATE
Descriptor:Dynamin-1, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, MAGNESIUM ION
Authors:Kong, L., Wang, H., Fang, S., Canagarajah, B., Kehr, A.D., Rice, W.J., Hinshaw, J.E.
Deposit date:2018-06-02
Release date:2018-08-01
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Cryo-EM of the dynamin polymer assembled on lipid membrane.
Nature, 560, 2018
6DLV
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CRYO-EM OF THE GTP-BOUND HUMAN DYNAMIN-1 POLYMER ASSEMBLED ON THE MEMBRANE IN THE SUPER CONSTRICTED STATE
Descriptor:Dynamin-1
Authors:Kong, L., Wang, H., Fang, S., Canagarajah, B., Kehr, A.D., Rice, W.J., Hinshaw, J.E.
Deposit date:2018-06-02
Release date:2018-08-01
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:Cryo-EM of the dynamin polymer assembled on lipid membrane.
Nature, 560, 2018
4QGT
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THE CRYSTAL STRUCTURE OF HUMAN IGG FC DOMAIN WITH ENHANCED AROMATIC SEQUON
Descriptor:Hepatitis B virus receptor binding protein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kong, L., Connelly, S.C., Wilson, I.A.
Deposit date:2014-05-25
Release date:2015-04-08
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon.
Acs Chem.Biol., 11, 2016
4RNR
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTI-HIV ANTIBODY PGT130
Descriptor:PGT130 Heavy Chain, PGT130 Light Chain, N-ACETYL-D-GLUCOSAMINE
Authors:Kong, L., Wilson, I.A.
Deposit date:2014-10-24
Release date:2014-11-19
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (2.758 Å)
Cite:Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope.
J.Virol., 89, 2015
5UXQ
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STRUCTURE OF ANTI-HIV TRIMER APEX ANTIBODY PGT143
Descriptor:PGT143 Fab Heavy Chain, PGT143 Fab Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2017-02-23
Release date:2017-04-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.415 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic Beta-Hairpin Structure
Immunity, 46, 2017
3JWD
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STRUCTURE OF HIV-1 GP120 WITH GP41-INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY
Descriptor:HIV-1 GP120 ENVELOPE GLYCOPROTEIN, T-cell surface glycoprotein CD4, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M., Majeed, S., Ban, Y.A., Chen, L., Huang, C.C., Kong, L., Kwon, Y.D., Stuckey, J., Zhou, T., Robinson, J.E., Schief, W.R., Sodroski, J., Wyatt, R., Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
4R26
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CRYSTAL STRUCTURE OF HUMAN FAB PGT124, A BROADLY NEUTRALIZING AND POTENT HIV-1 NEUTRALIZING ANTIBODY
Descriptor:PGR124-Light Chain, PGT124-Heavy Chain, GLYCEROL
Authors:Garces, F., Kong, L., Wilson, I.A.
Deposit date:2014-08-08
Release date:2014-10-08
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.4969 Å)
Cite:Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies.
Cell(Cambridge,Mass.), 159, 2014
5ID3
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SOLUTION STRUCTURE OF THE PORE-FORMING REGION OF C. ELEGANS MITOCHONDRIAL CALCIUM UNIPORTER (MCU)
Descriptor:Mitochondrial Calcium Uniporter
Authors:Oxenoid, K., Dong, Y., Cao, C., Cui, T., Sancak, Y., Markhard, A.L., Grabarek, Z., Kong, L., Liu, Z., Ouyang, B., Cong, Y., Mootha, V.K., Chou, J.J., Membrane Protein Structures by Solution NMR (MPSbyNMR)
Deposit date:2016-02-23
Release date:2016-05-04
Last modified:2017-09-27
Method:SOLUTION NMR
Cite:Architecture of the mitochondrial calcium uniporter.
Nature, 533, 2016
6BZU
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY 19B3
Descriptor:19B3 Heavy Chain, 19B3 Light Chain, E2 AS412 peptide
Authors:Tzarum, N., Alemn, F., Kong, L., Wilson, I.A., Law, M.
Deposit date:2017-12-26
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6IMM
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CRYO-EM STRUCTURE OF AN ALPHAVIRUS, SINDBIS VIRUS
Descriptor:Spike glycoprotein E1, Spike glycoprotein E2, Assembly protein E3, ...
Authors:Zhang, X., Ma, J., Chen, L.
Deposit date:2018-10-23
Release date:2019-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Implication for alphavirus host-cell entry and assembly indicated by a 3.5 angstrom resolution cryo-EM structure.
Nat Commun, 9, 2018
3JWO
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STRUCTURE OF HIV-1 GP120 WITH GP41-INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY
Descriptor:HIV-1 GP120 ENVELOPE GLYCOPROTEIN, T-cell surface glycoprotein CD4, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M., Majeed, S., Huang, C.C., Kwon, Y.D., Zhou, T., Robinson, J.E., Sodroski, J., Wyatt, R., Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
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