Author results

3QNF
  • Download 3qnf
  • View 3qnf
Molmil generated image of 3qnf
CRYSTAL STRUCTURE OF THE OPEN STATE OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:Endoplasmic reticulum aminopeptidase 1, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Harvey, D., Chaikuad, A., Allerston, C., Muniz, J.R.C., Raynor, J., Ugochukwu, E., Berridge, G., Wordsworth, B.P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-02-08
Release date:2011-02-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YD0
  • Download 2yd0
  • View 2yd0
Molmil generated image of 2yd0
CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Raynor, J., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (Erap1) Reveal the Molecular Basis for N-Terminal Peptide Trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
3EQ6
  • Download 3eq6
  • View 3eq6
Molmil generated image of 3eq6
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN A TERNARY COMPLEX WITH PRODUCTS
Descriptor:Acyl-coenzyme A synthetase ACSM2A, ADENOSINE MONOPHOSPHATE, Butyryl Coenzyme A
Authors:Pilka, E.S., Kochan, G., Yue, W.W., Bhatia, C., Von delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-09-30
Release date:2008-10-28
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
J.Mol.Biol., 388, 2009
4B87
  • Download 4b87
  • View 4b87
Molmil generated image of 4b87
CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1A
Descriptor:DNA CROSS-LINK REPAIR 1A PROTEIN, ZINC ION, 1,2-ETHANEDIOL
Authors:Allerston, C.K., Berridge, G., Carpenter, E.P., Kochan, G., Krojer, T., Mahajan, P., Vollmar, M., Yue, W.W., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-08-24
Release date:2012-11-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal Structure of Human DNA Cross-Link Repair 1A
To be Published
2JKU
  • Download 2jku
  • View 2jku
Molmil generated image of 2jku
CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF THE BIOTIN ACCEPTOR DOMAIN OF HUMAN PROPIONYL-COA CARBOXYLASE
Descriptor:PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL, TETRAETHYLENE GLYCOL
Authors:Healy, S., Yue, W.W., Kochan, G., Pilka, E.S., Murray, J.W., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Gravel, R.A., Oppermann, U.
Deposit date:2008-08-30
Release date:2008-09-09
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.
Biochemistry, 49, 2010
2VNA
  • Download 2vna
  • View 2vna
Molmil generated image of 2vna
STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1)
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U.
Deposit date:2008-02-01
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
To be Published
2VRE
  • Download 2vre
  • View 2vre
Molmil generated image of 2vre
CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3,5,DELTA2,4-DIENOYL COA ISOMERASE
Descriptor:DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, CHLORIDE ION
Authors:Yue, W., Guo, K., von Delft, F., Pilka, E., Murray, J., Roos, A., Kochan, G., Bountra, C., Arrowsmith, C., Wikstrom, M., Edwards, A., Oppermann, U.
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Human Peroxisomal Delta3,5, Delta2,4-Dienoyl Coa Isomerase (Ech1)
To be Published
2VSV
  • Download 2vsv
  • View 2vsv
Molmil generated image of 2vsv
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
Descriptor:RHOPHILIN-2
Authors:Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
Deposit date:2008-04-29
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2VX2
  • Download 2vx2
  • View 2vx2
Molmil generated image of 2vx2
CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASE DOMAIN- CONTAINING PROTEIN 3 (ECHDC3)
Descriptor:ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3
Authors:Yue, W.W., Guo, K., Kochan, G., Pilka, E., Murray, J.W., Salah, E., Cocking, R., Sun, Z., Roos, A.K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-06-30
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Enoyl Coenzyme a Hydratase Domain-Containing Protein 3 (Echdc3)
To be Published
2W2J
  • Download 2w2j
  • View 2w2j
Molmil generated image of 2w2j
CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE RELATED PROTEIN VIII
Descriptor:CARBONIC ANHYDRASE-RELATED PROTEIN, CHLORIDE ION, GLYCEROL, ...
Authors:Kramm, A., Muniz, J.R.C., Picaud, S.S., von Delft, F., Pilka, E.S., Yue, W.W., King, O.N.F., Kochan, G., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-10-31
Release date:2009-02-03
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Human Carbonic Anhydrase-Related Protein Viii Reveals the Basis for Catalytic Silencing.
Proteins, 76, 2009
2WWW
  • Download 2www
  • View 2www
Molmil generated image of 2www
CRYSTAL STRUCTURE OF METHYLMALONIC ACIDEMIA TYPE A PROTEIN
Descriptor:METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL, NONAETHYLENE GLYCOL, ...
Authors:Muniz, J.R.C., Gileadi, C., Froese, D.S., Yue, W.W., Pike, A.C.W., von Delft, F., Kochan, G., Sethi, R., Chaikuad, A., Pilka, E., Picaud, S., Phillips, C., Guo, K., Krysztofinska, E., Bray, J., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gravel, R.A., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-30
Release date:2009-11-17
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIJ
  • Download 2xij
  • View 2xij
Molmil generated image of 2xij
CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, 5'-DEOXYADENOSINE, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Vollmar, M., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIQ
  • Download 2xiq
  • View 2xiq
Molmil generated image of 2xiq
CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN AND MALONYL-COA
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, COBALAMIN, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Ugochukwu, E., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
3BIC
  • Download 3bic
  • View 3bic
Molmil generated image of 3bic
CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE
Descriptor:Methylmalonyl-CoA mutase, mitochondrial precursor, CHLORIDE ION
Authors:Ugochukwu, E., Kochan, G., Pantic, N., Parizotto, E., Pilka, E.S., Pike, A.C.W., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
J.Biol.Chem., 285, 2010
3CYN
  • Download 3cyn
  • View 3cyn
Molmil generated image of 3cyn
THE STRUCTURE OF HUMAN GPX8
Descriptor:Probable glutathione peroxidase 8, SULFATE ION, GLYCEROL
Authors:Kavanagh, K.L., Johansson, C., Yue, W.W., Kochan, G., Pike, A.C.W., Murray, J., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-04-25
Release date:2008-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of human GPX8
To be Published
3F3S
  • Download 3f3s
  • View 3f3s
Molmil generated image of 3f3s
THE CRYSTAL STRUCTURE OF HUMAN LAMBDA-CRYSTALLIN, CRYL1
Descriptor:Lambda-crystallin homolog, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
Authors:Ugochukwu, E., Johansson, C., Yue, W.W., Kochan, G., Pilka, E., Kramm, A., Pike, A.C.W., Filippakopoulos, P., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-10-31
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of Human Lambda-Crystallin, CRYL1
To be Published
3FE4
  • Download 3fe4
  • View 3fe4
Molmil generated image of 3fe4
CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE VI
Descriptor:Carbonic anhydrase 6, MAGNESIUM ION, GLYCEROL
Authors:Pilka, E.S., Kochan, G., Krysztofinska, E., Muniz, J., Yue, W.W., Roos, A.K., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-11-27
Release date:2008-12-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development
Biochem.Biophys.Res.Commun., 419, 2012
3K2O
  • Download 3k2o
  • View 3k2o
Molmil generated image of 3k2o
STRUCTURE OF AN OXYGENASE
Descriptor:Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, NICKEL (II) ION, SODIUM ION, ...
Authors:Krojer, T., McDonough, M.A., Clifton, I.J., Mantri, M., Ng, S.S., Pike, A.C.W., Butler, D.S., Webby, C.J., Kochan, G., Bhatia, C., Bray, J.E., Chaikuad, A., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Schofield, C.J., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-09-30
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.
J.Mol.Biol., 401, 2010
3OOY
  • Download 3ooy
  • View 3ooy
Molmil generated image of 3ooy
CRYSTAL STRUCTURE OF HUMAN TRANSKETOLASE (TKT)
Descriptor:Transketolase, THIAMIN DIPHOSPHATE, CALCIUM ION, ...
Authors:Krojer, T., Krysztofinska, E., Guo, K., Pilka, E., Kochan, G., Chaikuad, A., Vollmar, M., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-11-17
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of human Transketolase (TKT)
To be Published
5APA
  • Download 5apa
  • View 5apa
Molmil generated image of 5apa
CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASE ISOFORM A
Descriptor:ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE, NICKEL (II) ION, (2S)-2-hydroxybutanedioic acid, ...
Authors:Krojer, T., Kochan, G., Pfeffer, I., McDonough, M.A., Pilka, E., Hozjan, V., Allerston, C., Muniz, J.R., Chaikuad, A., Gileadi, O., Kavanagh, K., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2015-09-15
Release date:2015-09-23
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Human Aspartate Beta- Hydroxylase Isoform A
To be Published
2VZE
  • Download 2vze
  • View 2vze
Molmil generated image of 2vze
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH AMP
Descriptor:ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL, ADENOSINE MONOPHOSPHATE, ...
Authors:Yue, W.W., Kochan, G.T., Pilka, E.S., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wikstrom, M., Bountra, C., Oppermann, U.
Deposit date:2008-07-31
Release date:2008-10-14
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
J.Mol.Biol., 388, 2009
2WD9
  • Download 2wd9
  • View 2wd9
Molmil generated image of 2wd9
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH IBUPROFEN
Descriptor:ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL, IBUPROFEN, ...
Authors:Yue, W.W., Kochan, G.T., Pilka, E.S., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2009-03-21
Release date:2009-04-21
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
J.Mol.Biol., 388, 2009
3B7W
  • Download 3b7w
  • View 3b7w
Molmil generated image of 3b7w
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A, WITH L64P MUTATION
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
3C5E
  • Download 3c5e
  • View 3c5e
Molmil generated image of 3c5e
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH ATP
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
3DAY
  • Download 3day
  • View 3day
Molmil generated image of 3day
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH AMP-CPP
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Yue, W.W., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wikstrom, M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-07-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
<12>