2VZE

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP

Summary for 2VZE

Entry DOI	10.2210/pdb2vze/pdb
Descriptor	ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	ligase, metal-binding, transit peptide, lipid metabolism, nucleotide-binding, atp-binding, adenylate-forming enzyme, fatty acid metabolism, fatty acid-coa ligase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	3
Total formula weight	191069.65
Authors	Yue, W.W.,Kochan, G.T.,Pilka, E.S.,Bhatia, C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wikstrom, M.,Bountra, C.,Oppermann, U. (deposition date: 2008-07-31, release date: 2008-10-14, Last modification date: 2023-12-13)
Primary citation	Kochan, G.,Pilka, E.S.,Delft, F.V.,Oppermann, U.,Yue, W.W. Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A. J.Mol.Biol., 388:997-, 2009 Cited by PubMed: 19345228 DOI: 10.1016/J.JMB.2009.03.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation