2VZE
Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006637 | biological_process | acyl-CoA metabolic process |
| A | 0015645 | molecular_function | fatty acid ligase activity |
| A | 0016405 | molecular_function | CoA-ligase activity |
| A | 0018858 | molecular_function | benzoate-CoA ligase activity |
| A | 0031955 | molecular_function | short-chain fatty acid-CoA ligase activity |
| A | 0031956 | molecular_function | medium-chain fatty acid-CoA ligase activity |
| A | 0036112 | biological_process | medium-chain fatty-acyl-CoA metabolic process |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0070328 | biological_process | triglyceride homeostasis |
| A | 0102391 | molecular_function | decanoate-CoA ligase activity |
| B | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006637 | biological_process | acyl-CoA metabolic process |
| B | 0015645 | molecular_function | fatty acid ligase activity |
| B | 0016405 | molecular_function | CoA-ligase activity |
| B | 0018858 | molecular_function | benzoate-CoA ligase activity |
| B | 0031955 | molecular_function | short-chain fatty acid-CoA ligase activity |
| B | 0031956 | molecular_function | medium-chain fatty acid-CoA ligase activity |
| B | 0036112 | biological_process | medium-chain fatty-acyl-CoA metabolic process |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0070328 | biological_process | triglyceride homeostasis |
| B | 0102391 | molecular_function | decanoate-CoA ligase activity |
| C | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0006637 | biological_process | acyl-CoA metabolic process |
| C | 0015645 | molecular_function | fatty acid ligase activity |
| C | 0016405 | molecular_function | CoA-ligase activity |
| C | 0018858 | molecular_function | benzoate-CoA ligase activity |
| C | 0031955 | molecular_function | short-chain fatty acid-CoA ligase activity |
| C | 0031956 | molecular_function | medium-chain fatty acid-CoA ligase activity |
| C | 0036112 | biological_process | medium-chain fatty-acyl-CoA metabolic process |
| C | 0042593 | biological_process | glucose homeostasis |
| C | 0070328 | biological_process | triglyceride homeostasis |
| C | 0102391 | molecular_function | decanoate-CoA ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1570 |
| Chain | Residue |
| C | MET483 |
| C | HIS485 |
| C | VAL488 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE AMP A 1570 |
| Chain | Residue |
| A | TYR361 |
| A | GLY362 |
| A | GLN363 |
| A | THR364 |
| A | ASP446 |
| A | PHE458 |
| A | ARG461 |
| A | ASN467 |
| A | ARG472 |
| A | HOH2157 |
| A | HOH2212 |
| A | HOH2215 |
| A | HOH2256 |
| A | TRP265 |
| A | GLY338 |
| A | GLU339 |
| A | SER340 |
| A | GLU359 |
| A | SER360 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE AMP C 1571 |
| Chain | Residue |
| C | TRP265 |
| C | GLY338 |
| C | GLU339 |
| C | SER340 |
| C | GLU359 |
| C | SER360 |
| C | TYR361 |
| C | GLY362 |
| C | GLN363 |
| C | THR364 |
| C | ASP446 |
| C | PHE458 |
| C | ARG461 |
| C | ASN467 |
| C | ARG472 |
| C | HOH2093 |
| C | HOH2163 |
| C | HOH2164 |
| C | HOH2165 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AMP B 1570 |
| Chain | Residue |
| B | TRP265 |
| B | GLY338 |
| B | GLU339 |
| B | SER340 |
| B | GLU359 |
| B | SER360 |
| B | TYR361 |
| B | GLY362 |
| B | GLN363 |
| B | THR364 |
| B | ASP446 |
| B | PHE458 |
| B | ARG461 |
| B | ARG472 |
| B | HOH2145 |
| B | HOH2233 |
| B | HOH2234 |
Functional Information from PROSITE/UniProt
| site_id | PS00455 |
| Number of Residues | 12 |
| Details | AMP_BINDING Putative AMP-binding domain signature. IYFTSGTSGlPK |
| Chain | Residue | Details |
| A | ILE218-LYS229 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19345228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19345228","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of L64P mutant of human acyl-CoA synthetase medium-chain family member 2A.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68CK6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
