3B7W

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A, with L64P mutation

Summary for 3B7W

DescriptorAcyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsmiddle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, structural genomics consortium, sgc, atp-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding, transit peptide, ligase
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion matrix  Q08AH3
Total number of polymer chains1
Total molecular weight63592.77
Authors
Pilka, E.S.,Kochan, G.T.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2007-10-31, release date: 2007-11-27, Last modification date: 2018-01-31)
Primary citation
Kochan, G.,Pilka, E.S.,von Delft, F.,Oppermann, U.,Yue, W.W.
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388:997-1008, 2009
PubMed: 19345228 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2009.03.064
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.207400.7%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3b7w
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Molmil generated image of 3b7w
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Molmil generated image of 3b7w
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3b7w.pdb1.gz [278.6 KB])