2XIQ

Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA

Summary for 2XIQ

Related2XIJ
DescriptorMETHYLMALONYL-COA MUTASE, MITOCHONDRIAL, COBALAMIN, 5'-DEOXYADENOSINE, ... (5 entities in total)
Functional Keywordsorganic aciduria, isomerase, metabolic disease, vitamin b12
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMitochondrion matrix P22033
Total number of polymer chains2
Total molecular weight174542
Authors
Yue, W.W.,Froese, D.S.,Kochan, G.,Chaikuad, A.,Krojer, T.,Muniz, J.,Ugochukwu, E.,Arrowsmith, C.,Weigelt, J.,Edwards, A.,Bountra, C.,Oppermann, U. (deposition date: 2010-06-30, release date: 2010-09-29, Last modification date: 2012-10-31)
Primary citation
Froese, D.S.,Kochan, G.,Muniz, J.,Wu, X.,Gileadi, C.,Ugochukwu, E.,Krysztofinska, E.,Gravel, R.A.,Oppermann, U.,Yue, W.W.
Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285:38204-, 2010
PubMed: 20876572 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M110.177717
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20050.1%0.9%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 2xiq
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