2XIQ

Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL	polymer	762	84835.8	2	UniProt (P22033) Pfam (PF01642) Pfam (PF02310)	HOMO SAPIENS (HUMAN)	MCM, METHYLMALONYL-COA ISOMERASE
2	C, F (A, B)	COBALAMIN	non-polymer		1330.4	2	Chemie (B12)
3	D, G (A, B)	5'-DEOXYADENOSINE	non-polymer		251.2	2	Chemie (5AD)
4	E, H (A, B)	MALONYL-COENZYME A	non-polymer		853.6	2	Chemie (MLC)
5	I, J (A, B)	water	water		18.0	1106	Chemie (HOH)

Sequence modifications

A, B: 12 - 750 (UniProt: P22033)

PDB	External Database	Details
Met 11	-	expression tag
Ala 751	-	expression tag
Glu 752	-	expression tag
Asn 753	-	expression tag
Leu 754	-	expression tag
Tyr 755	-	expression tag
Phe 756	-	expression tag
Gln 757	-	expression tag
Ser 758	-	expression tag
His 759	-	expression tag
His 760	-	expression tag
His 761	-	expression tag
His 762	-	expression tag
His 763	-	expression tag
His 764	-	expression tag
Asp 765	-	expression tag
Tyr 766	-	expression tag
Lys 767	-	expression tag
Asp 768	-	expression tag
Asp 769	-	expression tag
Asp 770	-	expression tag
Asp 771	-	expression tag
Lys 772	-	expression tag
Thr 499	Ala 499	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	169671.6
Non-Polymers*	Number of molecules	6
	Total formula weight	4870.4
All*	Total formula weight	174542.0

*Water molecules are not included.