3C5E

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with ATP

Summary for 3C5E

Entry DOI	10.2210/pdb3c5e/pdb
Related	3B7W
Descriptor	Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, structural genomics consortium, sgc, atp-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix : Q08AH3
Total number of polymer chains	1
Total formula weight	64175.50
Authors	Pilka, E.S.,Kochan, G.T.,Bhatia, C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-31, release date: 2008-02-26, Last modification date: 2023-08-30)
Primary citation	Kochan, G.,Pilka, E.S.,von Delft, F.,Oppermann, U.,Yue, W.W. Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. J.Mol.Biol., 388:997-1008, 2009 Cited by PubMed: 19345228 DOI: 10.1016/j.jmb.2009.03.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation