3C5E

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0015645	molecular_function	fatty acid ligase activity
A	0016405	molecular_function	CoA-ligase activity
A	0016874	molecular_function	ligase activity
A	0016878	molecular_function	acid-thiol ligase activity
A	0018858	molecular_function	benzoate-CoA ligase activity
A	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
A	0036112	biological_process	medium-chain fatty-acyl-CoA metabolic process
A	0042593	biological_process	glucose homeostasis
A	0046872	molecular_function	metal ion binding
A	0070328	biological_process	triglyceride homeostasis
A	0102391	molecular_function	decanoate-CoA ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 701

Chain	Residue
A	MET483
A	HIS485
A	VAL488
A	HOH1179
A	HOH1365

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 702

Chain	Residue
A	HOH915
A	HOH916
A	ATP801
A	HOH911
A	HOH912
A	HOH913

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 703

Chain	Residue
A	LEU288
A	PRO289
A	LYS290
A	PHE291
A	HOH1002

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 704

Chain	Residue
A	ARG316
A	LEU342
A	THR345

---

site_id	AC5
Number of Residues	32
Details	BINDING SITE FOR RESIDUE ATP A 801

Chain	Residue
A	THR221
A	SER222
A	GLY223
A	THR224
A	SER225
A	LYS229
A	GLY338
A	GLU339
A	SER340
A	GLU359
A	SER360
A	TYR361
A	GLY362
A	GLN363
A	THR364
A	ASP446
A	PHE458
A	ARG461
A	LYS557
A	MG702
A	HOH910
A	HOH911
A	HOH912
A	HOH913
A	HOH914
A	HOH915
A	HOH916
A	HOH946
A	HOH1067
A	HOH1413
A	HOH1457
A	HOH1461

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS A 802

Chain	Residue
A	LEU79
A	MET80
A	TRP81
A	GLU85
A	ASN89
A	HOH998

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 803

Chain	Residue
A	TRP71
A	VAL116
A	PRO117
A	GLU118
A	LYS195
A	HOH1104
A	HOH1108

---

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. IYFTSGTSGlPK

Chain	Residue	Details
A	ILE218-LYS229

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19345228","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19345228","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of L64P mutant of human acyl-CoA synthetase medium-chain family member 2A.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68CK6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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