Author results

3QNF
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CRYSTAL STRUCTURE OF THE OPEN STATE OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:Endoplasmic reticulum aminopeptidase 1, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Harvey, D., Chaikuad, A., Allerston, C., Muniz, J.R.C., Raynor, J., Ugochukwu, E., Berridge, G., Wordsworth, B.P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2011-02-08
Release date:2011-02-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YD0
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CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Raynor, J., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (Erap1) Reveal the Molecular Basis for N-Terminal Peptide Trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
3EQ6
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN A TERNARY COMPLEX WITH PRODUCTS
Descriptor:Acyl-coenzyme A synthetase ACSM2A, ADENOSINE MONOPHOSPHATE, Butyryl Coenzyme A
Authors:Pilka, E.S., Kochan, G., Yue, W.W., Bhatia, C., Von delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-09-30
Release date:2008-10-28
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
J.Mol.Biol., 388, 2009
4B87
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CRYSTAL STRUCTURE OF HUMAN DNA CROSS-LINK REPAIR 1A
Descriptor:DNA CROSS-LINK REPAIR 1A PROTEIN, ZINC ION, 1,2-ETHANEDIOL
Authors:Allerston, C.K., Berridge, G., Carpenter, E.P., Kochan, G., Krojer, T., Mahajan, P., Vollmar, M., Yue, W.W., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-08-24
Release date:2012-11-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal Structure of Human DNA Cross-Link Repair 1A
To be Published
2JKU
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CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF THE BIOTIN ACCEPTOR DOMAIN OF HUMAN PROPIONYL-COA CARBOXYLASE
Descriptor:PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL, TETRAETHYLENE GLYCOL
Authors:Healy, S., Yue, W.W., Kochan, G., Pilka, E.S., Murray, J.W., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Gravel, R.A., Oppermann, U.
Deposit date:2008-08-30
Release date:2008-09-09
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.
Biochemistry, 49, 2010
2VNA
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STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1)
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U.
Deposit date:2008-02-01
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
To be Published
2VRE
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CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3,5,DELTA2,4-DIENOYL COA ISOMERASE
Descriptor:DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, CHLORIDE ION
Authors:Yue, W., Guo, K., von Delft, F., Pilka, E., Murray, J., Roos, A., Kochan, G., Bountra, C., Arrowsmith, C., Wikstrom, M., Edwards, A., Oppermann, U.
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Human Peroxisomal Delta3,5, Delta2,4-Dienoyl Coa Isomerase (Ech1)
To be Published
2VSV
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
Descriptor:RHOPHILIN-2
Authors:Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
Deposit date:2008-04-29
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2VX2
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CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASE DOMAIN- CONTAINING PROTEIN 3 (ECHDC3)
Descriptor:ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3
Authors:Yue, W.W., Guo, K., Kochan, G., Pilka, E., Murray, J.W., Salah, E., Cocking, R., Sun, Z., Roos, A.K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-06-30
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Enoyl Coenzyme a Hydratase Domain-Containing Protein 3 (Echdc3)
To be Published
2W2J
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CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE RELATED PROTEIN VIII
Descriptor:CARBONIC ANHYDRASE-RELATED PROTEIN, CHLORIDE ION, GLYCEROL, ...
Authors:Kramm, A., Muniz, J.R.C., Picaud, S.S., von Delft, F., Pilka, E.S., Yue, W.W., King, O.N.F., Kochan, G., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-10-31
Release date:2009-02-03
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Human Carbonic Anhydrase-Related Protein Viii Reveals the Basis for Catalytic Silencing.
Proteins, 76, 2009
2WWW
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CRYSTAL STRUCTURE OF METHYLMALONIC ACIDEMIA TYPE A PROTEIN
Descriptor:METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL, NONAETHYLENE GLYCOL, ...
Authors:Muniz, J.R.C., Gileadi, C., Froese, D.S., Yue, W.W., Pike, A.C.W., von Delft, F., Kochan, G., Sethi, R., Chaikuad, A., Pilka, E., Picaud, S., Phillips, C., Guo, K., Krysztofinska, E., Bray, J., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gravel, R.A., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-30
Release date:2009-11-17
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIJ
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, 5'-DEOXYADENOSINE, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Vollmar, M., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2XIQ
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN AND MALONYL-COA
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, COBALAMIN, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Ugochukwu, E., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
3BIC
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE
Descriptor:Methylmalonyl-CoA mutase, mitochondrial precursor, CHLORIDE ION
Authors:Ugochukwu, E., Kochan, G., Pantic, N., Parizotto, E., Pilka, E.S., Pike, A.C.W., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
J.Biol.Chem., 285, 2010
3CYN
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THE STRUCTURE OF HUMAN GPX8
Descriptor:Probable glutathione peroxidase 8, SULFATE ION, GLYCEROL
Authors:Kavanagh, K.L., Johansson, C., Yue, W.W., Kochan, G., Pike, A.C.W., Murray, J., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-04-25
Release date:2008-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of human GPX8
To be Published
3F3S
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THE CRYSTAL STRUCTURE OF HUMAN LAMBDA-CRYSTALLIN, CRYL1
Descriptor:Lambda-crystallin homolog, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
Authors:Ugochukwu, E., Johansson, C., Yue, W.W., Kochan, G., Pilka, E., Kramm, A., Pike, A.C.W., Filippakopoulos, P., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-10-31
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of Human Lambda-Crystallin, CRYL1
To be Published
3FE4
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE VI
Descriptor:Carbonic anhydrase 6, MAGNESIUM ION, GLYCEROL
Authors:Pilka, E.S., Kochan, G., Krysztofinska, E., Muniz, J., Yue, W.W., Roos, A.K., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-11-27
Release date:2008-12-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development
Biochem.Biophys.Res.Commun., 419, 2012
3K2O
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STRUCTURE OF AN OXYGENASE
Descriptor:Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, NICKEL (II) ION, SODIUM ION, ...
Authors:Krojer, T., McDonough, M.A., Clifton, I.J., Mantri, M., Ng, S.S., Pike, A.C.W., Butler, D.S., Webby, C.J., Kochan, G., Bhatia, C., Bray, J.E., Chaikuad, A., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Schofield, C.J., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-09-30
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.
J.Mol.Biol., 401, 2010
3O2G
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CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE DIOXYGENASE 1 (BBOX1)
Descriptor:Gamma-butyrobetaine dioxygenase, ZINC ION, N-OXALYLGLYCINE, ...
Authors:Krojer, T., Kochan, G., McDonough, M.A., von Delft, F., Leung, I.K.H., Henry, L., Claridge, T.D.W., Pilka, E., Ugochukwu, E., Muniz, J., Filippakopoulos, P., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Schofield, C.J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal Structure of Human gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 (BBOX1)
To be Published
3OOY
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CRYSTAL STRUCTURE OF HUMAN TRANSKETOLASE (TKT)
Descriptor:Transketolase, THIAMIN DIPHOSPHATE, CALCIUM ION, ...
Authors:Krojer, T., Krysztofinska, E., Guo, K., Pilka, E., Kochan, G., Chaikuad, A., Vollmar, M., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-11-17
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of human Transketolase (TKT)
To be Published
5APA
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CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASE ISOFORM A
Descriptor:ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE, NICKEL (II) ION, (2S)-2-hydroxybutanedioic acid, ...
Authors:Krojer, T., Kochan, G., Pfeffer, I., McDonough, M.A., Pilka, E., Hozjan, V., Allerston, C., Muniz, J.R., Chaikuad, A., Gileadi, O., Kavanagh, K., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2015-09-15
Release date:2015-09-23
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Human Aspartate Beta- Hydroxylase Isoform A
To be Published
2VZE
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH AMP
Descriptor:ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL, ADENOSINE MONOPHOSPHATE, ...
Authors:Yue, W.W., Kochan, G.T., Pilka, E.S., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wikstrom, M., Bountra, C., Oppermann, U.
Deposit date:2008-07-31
Release date:2008-10-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
J.Mol.Biol., 388, 2009
2WD9
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH IBUPROFEN
Descriptor:ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL, IBUPROFEN, ...
Authors:Yue, W.W., Kochan, G.T., Pilka, E.S., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2009-03-21
Release date:2009-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
J.Mol.Biol., 388, 2009
3B7W
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A, WITH L64P MUTATION
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
3C5E
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH ATP
Descriptor:Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, MAGNESIUM ION, ...
Authors:Pilka, E.S., Kochan, G.T., Bhatia, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
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