Author results

2NWC
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A 3.02 ANGSTROM CRYSTAL STRUCTURE OF WILD-TYPE APO GROEL IN A MONOCLINIC SPACE GROUP
Descriptor:60 kDa chaperonin
Authors:Kiser, P.D., Lodowski, D.T., Palczewski, K.
Deposit date:2006-11-14
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions
Acta Crystallogr.,Sect.F, 63, 2007
3E76
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CRYSTAL STRUCTURE OF WILD-TYPE GROEL WITH BOUND THALLIUM IONS
Descriptor:60 kDa chaperonin, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, THALLIUM (I) ION, ...
Authors:Kiser, P.D., Lorimer, G.H., Palczewski, K.
Deposit date:2008-08-17
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:Use of thallium to identify monovalent cation binding sites in GroEL.
Acta Crystallogr.,Sect.F, 65, 2009
3FSN
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CRYSTAL STRUCTURE OF RPE65 AT 2.14 ANGSTROM RESOLUTION
Descriptor:Retinal pigment epithelium-specific 65 kDa protein, FE (II) ION, TETRAETHYLENE GLYCOL
Authors:Kiser, P.D., Lodowski, D.T., Palczewski, K.
Deposit date:2009-01-11
Release date:2009-09-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc.Natl.Acad.Sci.USA, 106, 2009
4F2Z
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CRYSTAL STRUCTURE OF RPE65 IN A LIPID ENVIRONMENT
Descriptor:Retinoid isomerohydrolase, FE (II) ION
Authors:Kiser, P.D., Shi, W., Palczewski, K.
Deposit date:2012-05-08
Release date:2012-10-03
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F30
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STRUCTURE OF RPE65: P6522 CRYSTAL FORM GROWN IN AMMONIUM PHOSPHATE SOLUTION
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PHOSPHATE ION
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2012-05-08
Release date:2012-10-03
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F3A
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STRUCTURE OF RPE65: P6522 CRYSTAL FORM, IRIDIUM DERIVATIVE
Descriptor:Retinoid isomerohydrolase, IRIDIUM (III) ION, FE (II) ION
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2012-05-09
Release date:2012-10-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F3D
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STRUCTURE OF RPE65: P65 CRYSTAL FORM GROWN IN FOS-CHOLINE-10
Descriptor:Retinoid isomerohydrolase, FE (II) ION, 2-ETHOXYETHANOL
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2012-05-09
Release date:2012-10-03
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
Proc.Natl.Acad.Sci.USA, 109, 2012
4RSC
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH EMIXUSTAT AND PALMITATE
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Shi, W., Palczewski, K.
Deposit date:2014-11-07
Release date:2015-04-15
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
4RSE
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH MB-001 AND PALMITATE
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Shi, W., Palczewski, K.
Deposit date:2014-11-07
Release date:2015-04-15
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
4ZHK
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH MB-002
Descriptor:Retinoid isomerohydrolase, FE (II) ION, TETRAETHYLENE GLYCOL, ...
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2015-04-25
Release date:2015-05-27
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of RPE65 in complex with MB-002
To Be Published
5UL5
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH MB-004 AND PALMITATE
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2017-01-24
Release date:2017-05-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
J. Pharmacol. Exp. Ther., 362, 2017
5ULG
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH MB-008 AND PALMITATE
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2017-01-24
Release date:2017-05-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
J. Pharmacol. Exp. Ther., 362, 2017
3KVC
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CRYSTAL STRUCTURE OF BOVINE RPE65 AT 1.9 ANGSTROM RESOLUTION
Descriptor:Retinoid isomerohydrolase, FE (II) ION
Authors:Kiser, P.D., Lodowski, D.T., Golczak, M., Palczewski, K.
Deposit date:2009-11-29
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J.Biol.Chem., 285, 2010
3VAR
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CRYSTAL STRUCTURE OF DNPEP, ZNZN FORM
Descriptor:Aspartyl aminopeptidase, ZINC ION
Authors:Kiser, P.D., Chen, Y., Palczewski, K.
Deposit date:2011-12-29
Release date:2012-02-29
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insights into substrate specificity and metal activation of Mammalian tetrahedral aspartyl aminopeptidase.
J.Biol.Chem., 287, 2012
3VAT
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CRYSTAL STRUCTURE OF DNPEP, ZNMG FORM
Descriptor:Aspartyl aminopeptidase, ZINC ION, MAGNESIUM ION
Authors:Kiser, P.D., Chen, Y., Palczewski, K.
Deposit date:2011-12-29
Release date:2012-02-29
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into substrate specificity and metal activation of Mammalian tetrahedral aspartyl aminopeptidase.
J.Biol.Chem., 287, 2012
4DOT
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CRYSTAL STRUCTURE OF HUMAN HRASLS3.
Descriptor:Group XVI phospholipase A2
Authors:Kiser, P.D., Golczak, M., Sears, A.E., Lodowski, D.T., Palczewski, K.
Deposit date:2012-02-10
Release date:2012-05-30
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins.
J.Biol.Chem., 287, 2012
4DPZ
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CRYSTAL STRUCTURE OF HUMAN HRASLS2
Descriptor:HRAS-like suppressor 2
Authors:Kiser, P.D., Golczak, M., Sears, A.E., Lodowski, D.T., Palczewski, K.
Deposit date:2012-02-14
Release date:2012-05-30
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins.
J.Biol.Chem., 287, 2012
4RYX
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH EMIXUSTAT AND PALMITATE, P6522 CRYSTAL FORM
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2014-12-17
Release date:2015-05-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Janus face of primary amine compounds in visual cycle modulation
To be Published
4RYY
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH R-EMIXUSTAT AND PALMITATE
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2014-12-17
Release date:2015-05-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Janus face of primary amine compounds in visual cycle modulation
To be Published
4RYZ
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CRYSTAL STRUCTURE OF RPE65 IN COMPLEX WITH S-EMIXUSTAT AND PALMITATE
Descriptor:Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ...
Authors:Kiser, P.D., Palczewski, K.
Deposit date:2014-12-17
Release date:2015-05-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Janus face of primary amine compounds in visual cycle modulation
To be Published
6C7K
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CRYSTAL STRUCTURE OF AN ACO/RPE65 CHIMERA
Descriptor:Apocarotenoid-15,15'-oxygenase, FE (II) ION, CHLORIDE ION
Authors:Kiser, P.D., Shi, W.
Deposit date:2018-01-22
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Etiology of a dominant form of retinitis pigmentosa due to a D477G mutation in retinoid isomerase (RPE65)
To be published
6C7O
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CRYSTAL STRUCTURE OF D477G ACO/RPE65 CHIMERA, TRIGONAL CRYSTAL FORM
Descriptor:Apocarotenoid-15,15'-oxygenase, FE (II) ION
Authors:Kiser, P.D., Shi, W.
Deposit date:2018-01-23
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Etiology of a dominant form of retinitis pigmentosa due to a D477G mutation in retinoid isomerase (RPE65)
To be published
6C7P
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CRYSTAL STRUCTURE OF D477G ACO/RPE65 CHIMERA, MONOCLINIC CRYSTAL FORM
Descriptor:Apocarotenoid-15,15'-oxygenase, FE (II) ION
Authors:Kiser, P.D., Shi, W.
Deposit date:2018-01-23
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Etiology of a dominant form of retinitis pigmentosa due to a D477G mutation in retinoid isomerase (RPE65)
To be published
4OU8
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CRYSTAL STRUCTURE OF APOCAROTENOID OXYGENASE IN THE PRESENCE OF C8E6
Descriptor:Apocarotenoid-15,15'-oxygenase, FE (II) ION, CHLORIDE ION
Authors:Sui, X., Shi, W., Palczewski, K., Kiser, P.D.
Deposit date:2014-02-15
Release date:2014-03-19
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO).
J.Biol.Chem., 289, 2014
4OU9
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CRYSTAL STRUCTURE OF APOCAROTENOID OXYGENASE IN THE PRESENCE OF TRITON X-100
Descriptor:Apocarotenoid-15,15'-oxygenase, FE (II) ION, CHLORIDE ION
Authors:Sui, X., Palczewski, K., Kiser, P.D.
Deposit date:2014-02-15
Release date:2014-03-19
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO).
J.Biol.Chem., 289, 2014
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