4RYX

Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form

Summary for 4RYX

• Entry DOI: 10.2210/pdb4ryx/pdb
• Related: 3FSN 4RSC 4RYY 4RYZ
• Descriptor: Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (7 entities in total)
• Functional Keywords: 7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, isomerase, hydrolase
• Biological source: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• Cellular location: Cytoplasm: Q28175
• Total number of polymer chains: 1
• Total formula weight: 62066.42

Authors

Kiser, P.D.,Palczewski, K. (deposition date: 2014-12-17, release date: 2015-05-27, Last modification date: 2023-09-20)

• Primary citation: Zhang, J.,Kiser, P.D.,Badiee, M.,Palczewska, G.,Dong, Z.,Golczak, M.,Tochtrop, G.P.,Palczewski, K.; Molecular pharmacodynamics of emixustat in protection against retinal degeneration.; J.Clin.Invest., 125:2781-2794, 2015; PubMed: 26075817; DOI: 10.1172/JCI80950

Experimental method

X-RAY DIFFRACTION (2 Å)