Crystal structure of RPE65 in complex with R-emixustat and palmitate

Summary for 4RYY

Related3FSN 4RSC 4RYX 4RYZ
DescriptorRetinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (5 entities in total)
Functional Keywords7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, isomerase
Biological sourceBos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular locationCytoplasm Q28175
Total number of polymer chains2
Total molecular weight123021.37
Kiser, P.D.,Palczewski, K. (deposition date: 2014-12-17, release date: 2015-05-27)
Primary citation
Zhang, J.,Kiser, P.D.,Badiee, M.,Palczewska, G.,Golczak, M.,Tochtrop, G.P.,Palczewski, K.
The Janus face of primary amine compounds in visual cycle modulation
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.216200.9%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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