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4NTJ
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STRUCTURE OF THE HUMAN P2Y12 RECEPTOR IN COMPLEX WITH AN ANTITHROMBOTIC DRUG
Descriptor:P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-methylpyridine-3-carboxylate, CHOLESTEROL, ...
Authors:Zhang, K., Zhang, J., Gao, Z.-G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., Fenalti, G., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2013-12-02
Release date:2014-03-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Nature, 509, 2014
4PXZ
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CRYSTAL STRUCTURE OF P2Y12 RECEPTOR IN COMPLEX WITH 2MESADP
Descriptor:P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), ...
Authors:Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2014-03-25
Release date:2014-04-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
4PY0
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CRYSTAL STRUCTURE OF P2Y12 RECEPTOR IN COMPLEX WITH 2MESATP
Descriptor:P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), ...
Authors:Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2014-03-25
Release date:2014-04-30
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Agonist-bound structure of the human P2Y12 receptor
Nature, 509, 2014
5WF5
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AGONIST BOUND HUMAN A2A ADENOSINE RECEPTOR WITH D52N MUTATION AT 2.60 A RESOLUTION
Descriptor:Human A2a adenosine receptor T4L chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:White, K.L., Eddy, M.T., Gao, Z., Han, G.W., Hanson, M.A., Lian, T., Deary, A., Patel, N., Jacobson, K.A., Katritch, V., Stevens, R.C.
Deposit date:2017-07-11
Release date:2018-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.
Structure, 26, 2018
5WF6
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AGONIST BOUND HUMAN A2A ADENOSINE RECEPTOR WITH S91A MUTATION AT 2.90 A RESOLUTION
Descriptor:Human A2a adenosine receptor T4L chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:White, K.L., Eddy, M.T., Gao, Z., Han, G.W., Hanson, M.A., Lian, T., Deary, A., Patel, N., Jacobson, K.A., Katritch, V., Stevens, R.C.
Deposit date:2017-07-11
Release date:2018-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.
Structure, 26, 2018
6AQF
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CRYSTAL STRUCTURE OF A2AAR-BRIL IN COMPLEX WITH THE ANTAGONIST ZM241385 PRODUCED FROM PICHIA PASTORIS
Descriptor:Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, CHOLESTEROL, ...
Authors:Eddy, M.T., Lee, M.Y., Gao, Z., White, K., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K.M., Han, G.W., Jacobson, K.A., Stevens, R.C., Wuthrich, K.
Deposit date:2017-08-19
Release date:2018-01-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.
Cell, 172, 2018
4XNV
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THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH BPTU
Descriptor:P2Y purinoceptor 1, Rubredoxin, 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea, ...
Authors:Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R., Zhao, Q., Wu, B., GPCR Network (GPCR)
Deposit date:2015-01-16
Release date:2015-04-01
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
4XNW
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THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH MRS2500
Descriptor:P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1, [(1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate, ZINC ION
Authors:Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R., Zhao, Q., Wu, B., GPCR Network (GPCR)
Deposit date:2015-01-16
Release date:2015-04-01
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
3QAK
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AGONIST BOUND STRUCTURE OF THE HUMAN ADENOSINE A2A RECEPTOR
Descriptor:Adenosine receptor A2a,lysozyme chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Xu, F., Wu, H., Katritch, V., Han, G.W., Cherezov, V., Stevens, R., GPCR Network (GPCR)
Deposit date:2011-01-11
Release date:2011-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure of an agonist-bound human A2A adenosine receptor.
Science, 332, 2011