6AQF
Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris
Summary for 6AQF
Entry DOI | 10.2210/pdb6aqf/pdb |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, CHOLESTEROL, ... (7 entities in total) |
Functional Keywords | a2aar, gpcr, adenosine receptor, human a2aar_bril chimera, lcp, antagonist complex, pichia pastoris, membrane protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P29274 |
Total number of polymer chains | 1 |
Total formula weight | 53546.41 |
Authors | Eddy, M.T.,Lee, M.Y.,Gao, Z.,White, K.,Didenko, T.,Horst, R.,Audet, M.,Stanczak, P.,McClary, K.M.,Han, G.W.,Jacobson, K.A.,Stevens, R.C.,Wuthrich, K. (deposition date: 2017-08-19, release date: 2018-01-10, Last modification date: 2023-10-04) |
Primary citation | Eddy, M.T.,Lee, M.Y.,Gao, Z.G.,White, K.L.,Didenko, T.,Horst, R.,Audet, M.,Stanczak, P.,McClary, K.M.,Han, G.W.,Jacobson, K.A.,Stevens, R.C.,Wuthrich, K. Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor. Cell, 172:68-80.e12, 2018 Cited by PubMed: 29290469DOI: 10.1016/j.cell.2017.12.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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