6AQF

Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris

Summary for 6AQF

• Entry DOI: 10.2210/pdb6aqf/pdb
• Descriptor: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, CHOLESTEROL, ... (7 entities in total)
• Functional Keywords: a2aar, gpcr, adenosine receptor, human a2aar_bril chimera, lcp, antagonist complex, pichia pastoris, membrane protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P29274
• Total number of polymer chains: 1
• Total formula weight: 53546.41

Authors

Eddy, M.T.,Lee, M.Y.,Gao, Z.,White, K.,Didenko, T.,Horst, R.,Audet, M.,Stanczak, P.,McClary, K.M.,Han, G.W.,Jacobson, K.A.,Stevens, R.C.,Wuthrich, K. (deposition date: 2017-08-19, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Eddy, M.T.,Lee, M.Y.,Gao, Z.G.,White, K.L.,Didenko, T.,Horst, R.,Audet, M.,Stanczak, P.,McClary, K.M.,Han, G.W.,Jacobson, K.A.,Stevens, R.C.,Wuthrich, K.; Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.; Cell, 172:68-80.e12, 2018; PubMed: 29290469; DOI: 10.1016/j.cell.2017.12.004

Experimental method

X-RAY DIFFRACTION (2.51 Å)