6AQF

Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue ZMA A 1201

Chain	Residue
A	LEU85
A	ILE274
A	HOH1312
A	PHE168
A	GLU169
A	MET177
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	MET270

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CLR A 1202

Chain	Residue
A	PRO248
A	SER263
A	OLA1207

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CLR A 1203

Chain	Residue
A	CYS254
A	PHE255
A	CYS259
A	OLC1213

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CLR A 1204

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	ILE80
A	OLC1215

---

site_id	AC5
Number of Residues	4
Details	binding site for residue OLB A 1205

Chain	Residue
A	HIS75
A	MET140
A	TYR179
A	OLC1214

---

site_id	AC6
Number of Residues	4
Details	binding site for residue OLA A 1206

Chain	Residue
A	THR65
A	PHE70
A	OLA1207
A	OLC1213

---

site_id	AC7
Number of Residues	5
Details	binding site for residue OLA A 1207

Chain	Residue
A	PHE255
A	CYS262
A	CLR1202
A	OLA1206
A	OLC1213

---

site_id	AC8
Number of Residues	2
Details	binding site for residue OLA A 1208

Chain	Residue
A	TRP268
A	OLA1212

---

site_id	AC9
Number of Residues	4
Details	binding site for residue OLA A 1209

Chain	Residue
A	GLY5
A	LEU267
A	TYR271
A	OLA1212

---

site_id	AD1
Number of Residues	2
Details	binding site for residue OLA A 1210

Chain	Residue
A	ILE3
A	SER7

---

site_id	AD2
Number of Residues	4
Details	binding site for residue OLA A 1211

Chain	Residue
A	ALA97
A	ASP101
A	VAL116
A	ILE124

---

site_id	AD3
Number of Residues	3
Details	binding site for residue OLA A 1212

Chain	Residue
A	TYR290
A	OLA1208
A	OLA1209

---

site_id	AD4
Number of Residues	7
Details	binding site for residue OLC A 1213

Chain	Residue
A	THR65
A	PHE70
A	CYS71
A	CLR1203
A	OLA1206
A	OLA1207
A	HOH1304

---

site_id	AD5
Number of Residues	4
Details	binding site for residue OLC A 1214

Chain	Residue
A	TYR179
A	OLB1205
A	OLC1215
A	OLC1216

---

site_id	AD6
Number of Residues	3
Details	binding site for residue OLC A 1215

Chain	Residue
A	PHE258
A	CLR1204
A	OLC1214

---

site_id	AD7
Number of Residues	2
Details	binding site for residue OLC A 1216

Chain	Residue
A	OLC1214
A	HOH1307

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18832607","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18832607","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21593763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YDO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---