8CRC

Structure of human Plk1 PBD in complex with Allopole-A

Summary for 8CRC

Entry DOI	10.2210/pdb8crc/pdb
Descriptor	Serine/threonine-protein kinase PLK1, GLYCEROL, 7-chloro-4-(cyclopropylmethyl)-1-thioxo-2,4-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one, ... (4 entities in total)
Functional Keywords	kinase, serine/threonine protein kinase, small molecule, allosteric inhibitor, cell cycle, localization, cell division, mitosis, nucleus, phosphoprotein, transferase, phosphopeptide binding domain, transferase-inhibitor complex
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	26773.02
Authors	Kirsch, K.,Park, J.E.,Lee, K.S. (deposition date: 2023-03-08, release date: 2023-08-16, Last modification date: 2023-08-30)
Primary citation	Park, J.E.,Kirsch, K.,Lee, H.,Oliva, P.,Ahn, J.I.,Ravishankar, H.,Zeng, Y.,Fox, S.D.,Kirby, S.A.,Badhwar, P.,Andresson, T.,Jacobson, K.A.,Lee, K.S. Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. Proc.Natl.Acad.Sci.USA, 120:e2305037120-e2305037120, 2023 Cited by PubMed: 37603740 DOI: 10.1073/pnas.2305037120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation