8HB0
 
 | | Structure of human SGLT2-MAP17 complex with TA1887 | | Descriptor: | (2R,3R,4S,5S,6R)-2-[3-[(4-cyclopropylphenyl)methyl]-4-fluoranyl-indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-10-27 | | Release date: | 2023-11-01 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8HG7
 | | Structure of human SGLT2-MAP17 complex with Sotagliflozin | | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-14 | | Release date: | 2023-11-15 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8HEZ
 | | Structure of human SGLT2-MAP17 complex with Dapagliflozin | | Descriptor: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-09 | | Release date: | 2023-11-15 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8HDH
 | | Structure of human SGLT2-MAP17 complex with Canagliflozin | | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methyl-phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-04 | | Release date: | 2023-11-08 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8HIN
 | | Structure of human SGLT2-MAP17 complex with Phlorizin | | Descriptor: | 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | Authors: | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | Deposit date: | 2022-11-21 | | Release date: | 2023-11-22 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8WT7
 | | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange locked state | | Descriptor: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishimasu, H. | | Deposit date: | 2023-10-18 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural mechanism of bridge RNA-guided recombination.
Nature, 630, 2024
|
|
8WT8
 | | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the post-strand exchange state (Holliday junction intermediate) | | Descriptor: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishimasu, H. | | Deposit date: | 2023-10-18 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural mechanism of bridge RNA-guided recombination.
Nature, 630, 2024
|
|
8WT6
 | | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the pre-strand exchange state | | Descriptor: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishimasu, H. | | Deposit date: | 2023-10-18 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural mechanism of bridge RNA-guided recombination.
Nature, 630, 2024
|
|
8WT9
 | | Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, donor DNA, and target DNA in the post-strand exchange state (Holliday junction resolution) | | Descriptor: | IS621 transposase, MAGNESIUM ION, bridge RNA, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishimasu, H. | | Deposit date: | 2023-10-18 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural mechanism of bridge RNA-guided recombination.
Nature, 630, 2024
|
|
7DY0
 | |
7EFD
 | | 1.77 A cryo-EM structure of Streptavidin using first 40 frames (corresponding to about 40 e/A^2 total dose) | | Descriptor: | BIOTIN, Streptavidin | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Kotecha, A, Nureki, O. | | Deposit date: | 2021-03-21 | | Release date: | 2021-04-28 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (1.77 Å) | | Cite: | 1.77 A cryo-EM structure of Streptavidin using first 40 frames (corresponding to about 40e/A^2 total dose)
To Be Published
|
|
7EFC
 | | 1.70 A cryo-EM structure of streptavidin | | Descriptor: | BIOTIN, Streptavidin | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Kotecha, A, Nureki, O. | | Deposit date: | 2021-03-21 | | Release date: | 2021-04-28 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (1.7 Å) | | Cite: | 1.70 A cryo-EM structure of streptavidin using all frames (corresponding to 70 e/A^2 total dose)
To Be Published
|
|
6K7H
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7N
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1P state) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7I
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7J
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7G
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7K
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP-Pi state) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7L
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2P state class2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
6K7M
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2Pi-PL state) | | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
|
|
7E2E
 | | Crystal structure of the Estrogen-Related Receptor alpha (ERRalpha) ligand-binding domain (LBD) in complex with an agonist DS45500853 and a PGC-1alpha peptide | | Descriptor: | 1-[4-(3-tert-butyl-4-oxidanyl-phenoxy)phenyl]ethanone, IODIDE ION, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | | Authors: | Ito, S, Shinozuka, T, Kimura, T, Izumi, M, Wakabayashi, K. | | Deposit date: | 2021-02-05 | | Release date: | 2021-06-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery of a Novel Class of ERR alpha Agonists.
Acs Med.Chem.Lett., 12, 2021
|
|
1VKC
 | | Putative acetyl transferase from Pyrococcus furiosus | | Descriptor: | IODIDE ION, putative acetyl transferase | | Authors: | Habel, J.E, Liu, Z.-J, Tempel, W, Rose, J.P, Brereton, P.S, Izumi, M, Jenney Jr, F.E, Poole II, F.L, Shah, C, Sugar, F.J, Adams, M.W.W, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-05-11 | | Release date: | 2004-12-14 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Putative acetyl transferase from Pyrococcus furiosus
To be published
|
|
3APV
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein and amitriptyline complex | | Descriptor: | ACETIC ACID, Alpha-1-acid glycoprotein 2, Amitriptyline | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
|
|
3APX
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein and chlorpromazine complex | | Descriptor: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, ACETIC ACID, Alpha-1-acid glycoprotein 2 | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
|
|
3APW
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein and disopyramide complex | | Descriptor: | Alpha-1-acid glycoprotein 2, Disopyramide | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
|
|
