6K7J

Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class1)

Summary for 6K7J

• Entry DOI: 10.2210/pdb6k7j/pdb
• EMDB information: 9935
• Descriptor: Phospholipid-transporting ATPase, Cell cycle control protein 50A, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: flippase, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 173310.58

Authors

Hiraizumi, M.,Yamashita, K.,Nishizawa, T.,Nureki, O. (deposition date: 2019-06-07, release date: 2019-08-28, Last modification date: 2021-02-10)

• Primary citation: Hiraizumi, M.,Yamashita, K.,Nishizawa, T.,Nureki, O.; Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.; Science, 365:1149-1155, 2019; PubMed: 31416931; DOI: 10.1126/science.aay3353

Experimental method

ELECTRON MICROSCOPY (3.08 Å)