8HDH

Structure of human SGLT2-MAP17 complex with Canagliflozin

Summary for 8HDH

• Entry DOI: 10.2210/pdb8hdh/pdb
• EMDB information: 34673
• Descriptor: Sodium/glucose cotransporter 2, PDZK1-interacting protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: ion transport, sodium transport, sugar transport, symport, transport, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 86171.42

Authors

Hiraizumi, M.,Kishida, H.,Miyaguchi, I.,Nureki, O. (deposition date: 2022-11-04, release date: 2023-11-08, Last modification date: 2024-02-07)

• Primary citation: Hiraizumi, M.,Akashi, T.,Murasaki, K.,Kishida, H.,Kumanomidou, T.,Torimoto, N.,Nureki, O.,Miyaguchi, I.; Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.; Nat.Struct.Mol.Biol., 31:159-169, 2024; PubMed: 38057552; DOI: 10.1038/s41594-023-01134-0

Experimental method

ELECTRON MICROSCOPY (3.1 Å)