7E2E
Crystal structure of the Estrogen-Related Receptor alpha (ERRalpha) ligand-binding domain (LBD) in complex with an agonist DS45500853 and a PGC-1alpha peptide
Summary for 7E2E
| Entry DOI | 10.2210/pdb7e2e/pdb |
| Descriptor | Steroid hormone receptor ERR1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, 1-[4-(3-tert-butyl-4-oxidanyl-phenoxy)phenyl]ethanone, ... (5 entities in total) |
| Functional Keywords | nuclear receptor, complex, agonist, transcription |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 57270.97 |
| Authors | Ito, S.,Shinozuka, T.,Kimura, T.,Izumi, M.,Wakabayashi, K. (deposition date: 2021-02-05, release date: 2021-06-30, Last modification date: 2023-11-29) |
| Primary citation | Shinozuka, T.,Ito, S.,Kimura, T.,Izumi, M.,Wakabayashi, K. Discovery of a Novel Class of ERR alpha Agonists. Acs Med.Chem.Lett., 12:817-821, 2021 Cited by PubMed: 34055231DOI: 10.1021/acsmedchemlett.1c00100 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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