7E2E
Crystal structure of the Estrogen-Related Receptor alpha (ERRalpha) ligand-binding domain (LBD) in complex with an agonist DS45500853 and a PGC-1alpha peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue HVO A 601 |
| Chain | Residue |
| A | PHE328 |
| A | VAL369 |
| A | PHE382 |
| A | LEU405 |
| A | PHE495 |
| A | VAL504 |
| A | HOH701 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue IOD P 301 |
| Chain | Residue |
| P | ALA207 |
| Q | ALA207 |
| A | MET354 |
| B | MET354 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue HVO B 601 |
| Chain | Residue |
| B | PHE328 |
| B | VAL369 |
| B | PHE382 |
| B | LEU405 |
| B | PHE495 |
| B | HOH701 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Region: {"description":"AF-2 domain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
