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7LJC
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BU of 7ljc by Molmil
Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein
Descriptor: (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, ...
Authors:Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E.
Deposit date:2021-01-28
Release date:2021-03-03
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Cell Res., 31, 2021
7LJD
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BU of 7ljd by Molmil
Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein
Descriptor: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E.
Deposit date:2021-01-28
Release date:2021-03-03
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Cell Res., 31, 2021
7JVQ
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BU of 7jvq by Molmil
Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein
Descriptor: (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
Deposit date:2020-08-22
Release date:2021-02-24
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
7JVP
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BU of 7jvp by Molmil
Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
Descriptor: (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
Deposit date:2020-08-22
Release date:2021-02-24
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
7JV5
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BU of 7jv5 by Molmil
Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein
Descriptor: (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
Deposit date:2020-08-20
Release date:2021-02-24
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
7JVR
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BU of 7jvr by Molmil
Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein
Descriptor: Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
Deposit date:2020-08-22
Release date:2021-02-24
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
1I4O
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BU of 1i4o by Molmil
CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX
Descriptor: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE-7
Authors:Huang, Y, Park, Y.C, Rich, R.L, Segal, D, Myszka, D.G, Wu, H.
Deposit date:2001-02-22
Release date:2001-03-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Cell(Cambridge,Mass.), 104, 2001
1OMY
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BU of 1omy by Molmil
Crystal Structure of a Recombinant alpha-insect Toxin BmKaIT1 from the scorpion Buthus martensii Karsch
Descriptor: ACETIC ACID, Alpha-neurotoxin TX12, CHLORIDE ION
Authors:Huang, Y, Huang, Q, Chen, H, Tang, Y, Miyake, H, Kusunoki, M.
Deposit date:2003-02-26
Release date:2003-09-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallization and preliminary crystallographic study of rBmKalphaIT1, a recombinant alpha-insect toxin from the scorpion Buthus martensii Karsch.
Acta Crystallogr.,Sect.D, 59, 2003
3HTX
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BU of 3htx by Molmil
Crystal structure of small RNA methyltransferase HEN1
Descriptor: 5'-R(*GP*AP*UP*UP*UP*CP*UP*CP*UP*CP*UP*GP*CP*AP*AP*GP*CP*GP*AP*AP*AP*G)-3', 5'-R(P*UP*UP*CP*GP*CP*UP*UP*GP*CP*AP*GP*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*C)-3', HEN1, ...
Authors:Huang, Y, Ji, L.-J, Huang, Q.-C, Vassylyev, D.G, Chen, X.-M, Ma, J.-B.
Deposit date:2009-06-12
Release date:2009-09-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insights into mechanisms of the small RNA methyltransferase HEN1.
Nature, 461, 2009
9L2E
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BU of 9l2e by Molmil
Structure of SARM1 bound to M1 in the intermediate state 2
Descriptor: NAD(+) hydrolase SARM1
Authors:Huang, Y, Zhang, J, Zheng, S, Wang, X.
Deposit date:2024-12-17
Release date:2025-03-12
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:Stepwise Activation of SARM1 For Cell Death and Axon Degeneration Revealed by a Biosynthetic NMN Mimic
To Be Published
9L2D
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BU of 9l2d by Molmil
Structure of SARM1 bound to M1 in the intermediate state 1
Descriptor: NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Huang, Y, Zhang, J, Zheng, S, Wang, X.
Deposit date:2024-12-17
Release date:2025-03-12
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Stepwise Activation of SARM1 by a Biosynthetic NMN mimic
To Be Published
9L2G
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BU of 9l2g by Molmil
Structure of SARM1 2C-mutant bound to M1
Descriptor: NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Huang, Y, Zhang, J, Zheng, S, Wang, X.
Deposit date:2024-12-17
Release date:2025-03-19
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Stepwise Activation of SARM1 by a Biosynthetic NMN mimic
To Be Published
9L2F
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BU of 9l2f by Molmil
Structure of SARM1 bound to M1 and 1AD in the active state
Descriptor: NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Huang, Y, Zhang, J, Zheng, S, Wang, X.
Deposit date:2024-12-17
Release date:2025-03-19
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Stepwise Activation of SARM1 by a Biosynthetic NMN mimic
To Be Published
8HPI
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BU of 8hpi by Molmil
Crystal structure of Tyrosinase from Priestia megaterium
Descriptor: 1,2-ETHANEDIOL, Tyrosinase, ZINC ION
Authors:Huang, Y, Song, W.
Deposit date:2022-12-12
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structure of Tyrosinase from Priestia megaterium
To Be Published
3FIP
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BU of 3fip by Molmil
Crystal structure of Usher PapC translocation pore
Descriptor: Outer membrane usher protein papC
Authors:Huang, Y, Deisenhofer, J.
Deposit date:2008-12-12
Release date:2009-09-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.154 Å)
Cite:Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC.
Proc.Natl.Acad.Sci.USA, 106, 2009
1D2H
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BU of 1d2h by Molmil
CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE
Descriptor: GLYCINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y.
Deposit date:1999-10-11
Release date:1999-10-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1D2G
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BU of 1d2g by Molmil
CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER
Descriptor: GLYCINE N-METHYLTRANSFERASE
Authors:Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y.
Deposit date:1999-10-08
Release date:1999-10-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1D2C
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BU of 1d2c by Molmil
METHYLTRANSFERASE
Descriptor: PROTEIN (GLYCINE N-METHYLTRANSFERASE)
Authors:Huang, Y, Takusagawa, F.
Deposit date:1999-09-23
Release date:1999-10-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
2GFA
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BU of 2gfa by Molmil
double tudor domain complex structure
Descriptor: Jumonji domain-containing protein 2A, peptide
Authors:Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M.
Deposit date:2006-03-21
Release date:2006-05-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Science, 312, 2006
2GF7
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BU of 2gf7 by Molmil
Double tudor domain structure
Descriptor: Jumonji domain-containing protein 2A, SULFATE ION
Authors:Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M.
Deposit date:2006-03-21
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Science, 312, 2006
8SR9
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BU of 8sr9 by Molmil
Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium
Descriptor: CHOLESTEROL, MAGNESIUM ION, TRPM2 chanzyme
Authors:Huang, Y, Kumar, S, Lu, W, Du, J.
Deposit date:2023-05-05
Release date:2024-05-08
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 31, 2024
8SR8
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BU of 8sr8 by Molmil
Cryo-EM structure of TRPM2 chanzyme in the presence of EDTA (apo state)
Descriptor: CHOLESTEROL, TRPM2 chanzyme
Authors:Huang, Y, Kumar, S, Lu, W, Du, J.
Deposit date:2023-05-05
Release date:2024-05-08
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 31, 2024
8SRA
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BU of 8sra by Molmil
Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium
Descriptor: CALCIUM ION, CHOLESTEROL, TRPM2 chanzyme
Authors:Huang, Y, Kumar, S, Lu, W, Du, J.
Deposit date:2023-05-05
Release date:2024-05-08
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 31, 2024
8SRC
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BU of 8src by Molmil
Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ...
Authors:Huang, Y, Kumar, S, Lu, W, Du, J.
Deposit date:2023-05-05
Release date:2024-05-08
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 31, 2024
8SR7
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BU of 8sr7 by Molmil
Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate
Descriptor: 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ...
Authors:Huang, Y, Kumar, S, Lu, W, Du, J.
Deposit date:2023-05-05
Release date:2024-05-08
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (1.97 Å)
Cite:Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 31, 2024

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