9L2G

Structure of SARM1 2C-mutant bound to M1

This is a non-PDB format compatible entry.

Summary for 9L2G

• Entry DOI: 10.2210/pdb9l2g/pdb
• Related: 9L2D
• EMDB information: 62775
• Descriptor: NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate (2 entities in total)
• Functional Keywords: nad(+) hydrolase, cell death, apoptosis, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 674120.51

Authors

Huang, Y.,Zhang, J.,Zheng, S.,Wang, X. (deposition date: 2024-12-17, release date: 2025-03-19)

• Primary citation: Huang, Y.,Zhang, J.,Zheng, S.,Wang, X.; Stepwise Activation of SARM1 by a Biosynthetic NMN mimic; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.27 Å)