Author results

1CLD
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DNA-BINDING PROTEIN
Descriptor:CD2-LAC9, CADMIUM ION
Authors:Gardner, K.H., Coleman, J.E.
Deposit date:1995-06-06
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Kluyveromyces lactis LAC9 Cd2 Cys6 DNA-binding domain.
Nat.Struct.Biol., 2, 1995
4EQ1
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CRYSTAL STRUCTURE OF THE ARNT PAS-B HOMODIMER
Descriptor:Aryl hydrocarbon receptor nuclear translocator, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL
Authors:Gardner, K.H., Key, J.M.
Deposit date:2012-04-17
Release date:2013-04-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules.
Acs Chem.Biol., 8, 2013
2K7S
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HUMAN ARNT C-TERMINAL PAS DOMAIN, 3 RESIDUE IB SLIP
Descriptor:Aryl hydrocarbon receptor nuclear translocator
Authors:Evans, M.R., Card, P.B., Gardner, K.H.
Deposit date:2008-08-20
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:ARNT PAS-B has a fragile native state structure with an alternative beta-sheet register nearby in sequence space
Proc.Natl.Acad.Sci.USA, 106, 2009
170D
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SOLUTION STRUCTURE OF A DNA DODECAMER CONTAINING THE ANTI-NEOPLASTIC AGENT ARABINOSYLCYTOSINE: COMBINED USE OF NMR, RESTRAINED MOLECULAR DYNAMICS AND FULL RELAXATION MATRIX REFINEMENT
Descriptor:DNA/RNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*T)-R(P*CAR)-D(P*GP*CP*G)-3')
Authors:Schweitzer, B.I., Mikita, T., Kellogg, G.W., Gardner, K.H., Beardsley, G.P.
Deposit date:1994-03-14
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.
Biochemistry, 33, 1994
171D
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SOLUTION STRUCTURE OF A DNA DODECAMER CONTAINING THE ANTI-NEOPLASTIC AGENT ARABINOSYLCYTOSINE: COMBINED USE OF NMR, RESTRAINED MOLECULAR DYNAMICS AND FULL RELAXATION MATRIX REFINEMENT
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
Authors:Schweitzer, B.I., Mikita, T., Kellogg, G.W., Gardner, K.H., Beardsley, G.P.
Deposit date:1994-03-14
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.
Biochemistry, 33, 1994
1IK7
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CRYSTAL STRUCTURE OF THE UNCOMPLEXED PELLE DEATH DOMAIN
Descriptor:PROBABLE SERINE/THREONINE-PROTEIN KINASE Pelle, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Xiao, T., Gardner, K.H., Sprang, S.R.
Deposit date:2001-05-02
Release date:2002-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cosolvent-induced transformation of a death domain tertiary structure
Proc.Natl.Acad.Sci.USA, 99, 2002
1LL8
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STRUCTURE AND INTERACTIONS OF PAS KINASE N-TERMINAL PAS DOMAIN: MODEL FOR INTRAMOLECULAR KINASE REGULATION
Descriptor:PAS Kinase
Authors:Amezcua, C.A., Harper, S.M., Rutter, J., Gardner, K.H.
Deposit date:2002-04-26
Release date:2002-10-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation.
Structure, 10, 2002
1P97
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NMR STRUCTURE OF THE C-TERMINAL PAS DOMAIN OF HIF2A
Descriptor:Endothelial PAS domain protein 1
Authors:Erbel, P.J., Card, P.B., Karakuzu, O., Bruick, R.K., Gardner, K.H.
Deposit date:2003-05-09
Release date:2004-01-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor.
Proc.Natl.Acad.Sci.USA, 100, 2003
1X0O
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HUMAN ARNT C-TERMINAL PAS DOMAIN
Descriptor:Aryl hydrocarbon receptor nuclear translocator
Authors:Card, P.B., Erbel, P.J., Gardner, K.H.
Deposit date:2005-03-25
Release date:2005-10-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of ARNT PAS-B Dimerization: Use of a Common Beta-sheet Interface for Hetero- and Homodimerization.
J.Mol.Biol., 353, 2005
1YMZ
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CC45, AN ARTIFICIAL WW DOMAIN DESIGNED USING STATISTICAL COUPLING ANALYSIS
Descriptor:CC45
Authors:Socolich, M., Lockless, S.W., Russ, W.P., Lee, H., Gardner, K.H., Ranganathan, R.
Deposit date:2005-01-22
Release date:2005-09-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Evolutionary information for specifying a protein fold.
Nature, 437, 2005
2A24
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HADDOCK STRUCTURE OF HIF-2A/ARNT PAS-B HETERODIMER
Descriptor:Endothelial PAS domain protein 1, Aryl hydrocarbon receptor nuclear translocator
Authors:Card, P.B., Erbel, P.J., Gardner, K.H.
Deposit date:2005-06-21
Release date:2006-01-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
J.Mol.Biol., 353, 2005
2BYC
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BLRB - A BLUF PROTEIN, DARK STATE STRUCTURE
Descriptor:BLUE-LIGHT RECEPTOR OF THE BLUF-FAMILY, FLAVIN MONONUCLEOTIDE
Authors:Jung, A., Domratcheva, T., Tarutina, M., Wu, Q., Ko, W.H., Shoeman, R.L., Gomelsky, M., Gardner, K.H., Schlichting, I.
Deposit date:2005-07-29
Release date:2005-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Bacterial Bluf Photoreceptor: Insights Into Blue Light-Mediated Signal Transduction.
Proc.Natl.Acad.Sci.USA, 102, 2005
2F9S
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2ND CRYSTAL STRUCTURE OF A SOLUBLE DOMAIN OF RESA IN THE OXIDISED FORM
Descriptor:Thiol-disulfide oxidoreductase resA
Authors:Colbert, C.L., Wu, Q., Erbel, P.J.A., Gardner, K.H., Deisenhofer, J.
Deposit date:2005-12-06
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation
Proc.Natl.Acad.Sci.USA, 103, 2006
2HV1
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HADDOCK STRUCTURE OF ARNT PAS-B HOMODIMER
Descriptor:Aryl hydrocarbon receptor nuclear translocator
Authors:Card, P.B., Gardner, K.H.
Deposit date:2006-07-27
Release date:2007-08-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Practical aspects of using paramagnetic relaxation enhancements for protein docking: Application to the ARNT PAS-B homodimer
To be Published
2LRU
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SOLUTION STRUCTURE OF THE WNK1 AUTOINHIBITORY DOMAIN
Descriptor:Serine/threonine-protein kinase WNK1
Authors:Moon, T.M., Correa, F., Gardner, K.H., Goldsmith, E.J.
Deposit date:2012-04-13
Release date:2012-05-23
Last modified:2013-04-24
Method:SOLUTION NMR
Cite:Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain.
J.Mol.Biol., 425, 2013
2MSW
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LIGAND-INDUCED FOLDING OF A RECEIVER DOMAIN
Descriptor:Response regulator/sensor histidine kinase
Authors:Ocasio, V.J., Correa, F., Gardner, K.H.
Deposit date:2014-08-08
Release date:2015-02-11
Last modified:2015-04-08
Method:SOLUTION NMR
Cite:Ligand-induced folding of a two-component signaling receiver domain.
Biochemistry, 54, 2015
2N9U
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SOLUTION NMR STRUCTURE OF ERYTHROBACTER LITORALIS PHYR RESPONSE REGULATOR REC DOMAIN
Descriptor:Response regulator
Authors:Correa, F., Gardner, K.H.
Deposit date:2015-12-09
Release date:2016-09-07
Last modified:2016-12-28
Method:SOLUTION NMR
Cite:Basis of Mutual Domain Inhibition in a Bacterial Response Regulator.
Cell Chem Biol, 23, 2016
2VLG
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KINA PAS-A DOMAIN, HOMODIMER
Descriptor:SPORULATION KINASE A, CHLORIDE ION, ACETATE ION
Authors:Lee, J., Tomchick, D.R., Brautigam, C.A., Machius, M., Kort, R., Hellingwerf, K.J., Gardner, K.H.
Deposit date:2008-01-14
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Changes at the Kina Pas-A Dimerization Interface Influence Histidine Kinase Function.
Biochemistry, 47, 2008
3F1N
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CRYSTAL STRUCTURE OF A HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS, WITH INTERNALLY BOUND ETHYLENE GLYCOL.
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 1,2-ETHANEDIOL
Authors:Scheuermann, T.H., Tomchick, D.R., Machius, M., Guo, Y., Bruick, R.K., Gardner, K.H.
Deposit date:2008-10-28
Release date:2009-01-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.479 Å)
Cite:Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F1O
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CRYSTAL STRUCTURE OF THE HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS, WITH AN INTERNALLY-BOUND ARTIFICIAL LIGAND
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-[2-nitro-4-(trifluoromethyl)phenyl]morpholin-4-amine, ...
Authors:Scheuermann, T.H., Tomchick, D.R., Machius, M., Guo, Y., Bruick, R.K., Gardner, K.H.
Deposit date:2008-10-28
Release date:2009-01-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F1P
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CRYSTAL STRUCTURE OF A HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator
Authors:Scheuermann, T.H., Tomchick, D.R., Machius, M., Guo, Y., Bruick, R.K., Gardner, K.H.
Deposit date:2008-10-28
Release date:2009-01-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3H7W
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CRYSTAL STRUCTURE OF THE HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS WITH THE ARTIFICIAL LIGAND THS017
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline
Authors:Key, J.M., Scheuermann, T.H., Anderson, P.C., Daggett, V., Gardner, K.H.
Deposit date:2009-04-28
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
J.Am.Chem.Soc., 131, 2009
3H82
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CRYSTAL STRUCTURE OF THE HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS WITH THE ARTIFICIAL LIGAND THS020
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(furan-2-ylmethyl)-2-nitro-4-(trifluoromethyl)aniline
Authors:Key, J.M., Scheuermann, T.H., Anderson, P.C., Daggett, V., Gardner, K.H.
Deposit date:2009-04-28
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
J.Am.Chem.Soc., 131, 2009
3P4K
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THE THIRD CONFORMATION OF P38A MAP KINASE OBSERVED IN PHOSPHORYLATED P38A AND IN SOLUTION
Descriptor:Mitogen-activated protein kinase 14, MAP kinase 14
Authors:Akella, R., Min, X., Wu, Q., Gardner, K.H., Goldsmith, E.J.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution
Structure, 18, 2010
4GHI
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CRYSTAL STRUCTURE OF THE HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS IN COMPLEX WITH A BENZOXADIAZOLE ANTAGONIST
Descriptor:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Authors:Scheuermann, T.H., Key, J., Tambar, U.K., Bruick, R.K., Gardner, K.H.
Deposit date:2012-08-07
Release date:2013-02-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Nat.Chem.Biol., 9, 2013
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