4GHI

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a benzoxadiazole antagonist

Summary for 4GHI

Entry DOI	10.2210/pdb4ghi/pdb
Related	2HV1 3F1N 3F1O 3F1P 3H7W 3H82
Descriptor	Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine, ... (4 entities in total)
Functional Keywords	pas fold, protein : protein interactions, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (Potential): Q99814 Nucleus: P27540
Total number of polymer chains	2
Total formula weight	28090.05
Authors	Scheuermann, T.H.,Key, J.,Tambar, U.K.,Bruick, R.K.,Gardner, K.H. (deposition date: 2012-08-07, release date: 2013-02-27, Last modification date: 2023-09-13)
Primary citation	Scheuermann, T.H.,Li, Q.,Ma, H.W.,Key, J.,Zhang, L.,Chen, R.,Garcia, J.A.,Naidoo, J.,Longgood, J.,Frantz, D.E.,Tambar, U.K.,Gardner, K.H.,Bruick, R.K. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol., 9:271-276, 2013 Cited by PubMed: 23434853 DOI: 10.1038/nchembio.1185 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation