3H82

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS020

Summary for 3H82

Entry DOI	10.2210/pdb3h82/pdb
Related	1P97 1X0O 2A24 2B02 3F1N 3F1O 3F1P 3H7W
Descriptor	Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(furan-2-ylmethyl)-2-nitro-4-(trifluoromethyl)aniline, ... (4 entities in total)
Functional Keywords	pas domain, heterodimer, protein ligand complex., activator, angiogenesis, congenital erythrocytosis, developmental protein, differentiation, disease mutation, dna-binding, hydroxylation, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, alternative splicing, polymorphism
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (Potential): P27540 Nucleus: Q99814
Total number of polymer chains	2
Total formula weight	28067.60
Authors	Key, J.M.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H. (deposition date: 2009-04-28, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citation	Key, J.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H. Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B J.Am.Chem.Soc., 131:17647-17654, 2009 Cited by PubMed: 19950993 DOI: 10.1021/ja9073062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation