Author results

7KKJ
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STRUCTURE OF ANTI-SARS-COV-2 SPIKE NANOBODY MNB6
Descriptor:Synthetic nanobody mNb6, SULFATE ION, CHLORIDE ION
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
7KKK
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY NB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody Nb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
7KKL
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY MNB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody mNb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
2PI0
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CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER
Descriptor:PRDIII-I region of human interferon-B promoter strand 1, PRDIII-I region of human interferon-B promoter strand 2, Interferon regulatory factor 3
Authors:Escalante, C.R., Nistal-Villan, E., Leyi, S., Garcia-Sastre, A., Aggarwal, A.K.
Deposit date:2007-04-12
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.
Mol.Cell, 26, 2007
3PSE
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STRUCTURE OF A VIRAL OTU DOMAIN PROTEASE BOUND TO INTERFERON-STIMULATED GENE 15 (ISG15)
Descriptor:RNA polymerase, Ubiquitin-like protein ISG15, 3-AMINOPROPANE, ...
Authors:Bacik, J.P., James, T.W., Frias-Staheli, N., Garcia-Sastre, A., Mark, B.L.
Deposit date:2010-12-01
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PT2
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STRUCTURE OF A VIRAL OTU DOMAIN PROTEASE BOUND TO UBIQUITIN
Descriptor:RNA polymerase, Ubiquitin B, SULFATE ION, ...
Authors:James, T.W., Bacik, J.P., Frias-Staheli, N., Garcia-Sastre, A., Mark, B.L.
Deposit date:2010-12-02
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
Proc.Natl.Acad.Sci.USA, 108, 2011
7KDT
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HUMAN TOM70 IN COMPLEX WITH SARS COV2 ORF9B
Descriptor:Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:QCRG Structural Biology Consortium
Deposit date:2020-10-09
Release date:2020-10-21
Last modified:2020-11-04
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science, 2020
2LWD
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SOLUTION STRUCTURE OF SECOND CARD OF HUMAN RIG-I
Descriptor:Probable ATP-dependent RNA helicase DDX58
Authors:Dutta, K., Ferrage, F., Aggarwal, A.
Deposit date:2012-07-27
Release date:2012-10-31
Last modified:2012-12-26
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
Structure, 20, 2012
2LWE
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SOLUTION STRUCTURE OF MUTANT (T170E) SECOND CARD OF HUMAN RIG-I
Descriptor:Probable ATP-dependent RNA helicase DDX58
Authors:Dutta, K., Ferrage, F., Aggarwal, A.
Deposit date:2012-07-27
Release date:2012-10-31
Last modified:2012-12-26
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
Structure, 20, 2012
3O9Q
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EFFECTOR DOMAIN OF NS1 FROM A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9R
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EFFECTOR DOMAIN OF NS1 FROM INFLUENZA A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9S
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EFFECTOR DOMAIN OF INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9T
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EFFECTOR DOMAIN FROM INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1, HEXAETHYLENE GLYCOL
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9U
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EFFECTOR DOMAIN OF INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3OA9
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EFFECTOR DOMAIN OF INFLUENZA A/DUCK/ALBANY/76 NS1
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-05
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
6N34
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN NS1-BP
Descriptor:Influenza virus NS1A-binding protein
Authors:Zhang, K., Shang, G., Padavannil, A., Fontoura, B., Chook, Y.M.
Deposit date:2018-11-14
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6N3H
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CRYSTAL STRUCTURE OF KELCH DOMAIN OF THE HUMAN NS1 BINDING PROTEIN
Descriptor:Influenza virus NS1A-binding protein
Authors:Zhang, K., Shang, G., Padavannil, A., Fontoura, B.M.A., Chook, Y.M.
Deposit date:2018-11-15
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5V2A
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CRYSTAL STRUCTURE OF FAB H7.167 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A/SHANGHAI/02/2013 (H7N9)
Descriptor:Hemagglutinin, Light chain (kappa) of H7.167 antibody, Heavy chain of H7.167 antibody, ...
Authors:Zhang, H., Zhu, X., Wilson, I.A.
Deposit date:2017-03-03
Release date:2017-04-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.656 Å)
Cite:H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
J. Clin. Invest., 126, 2016
6E7G
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CRYSTAL STRUCTURE OF H5 HEMAGGLUTININ MUTANT Y161A FROM A/VIET NAM/1203/2004 H5N1 INFLUENZA VIRUS
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tzarum, N., Wilson, I.A.
Deposit date:2018-07-26
Release date:2019-06-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.094 Å)
Cite:N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.
Cell Rep, 27, 2019
6E7H
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CRYSTAL STRUCTURE OF H5 HEMAGGLUTININ MUTANT Y161A FROM A/VIET NAM/1203/2004 H5N1 INFLUENZA VIRUS IN COMPLEX WITH 3'-GCLN
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tzarum, N., Wilson, I.A.
Deposit date:2018-07-26
Release date:2019-06-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.
Cell Rep, 27, 2019
6N5A
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CRYSTAL STRUCTURE OF AN EQUINE H7 HEMAGGLUTININ FROM A/EQUINE/NY/49/73 (H7N7)
Descriptor:HEMAGGLUTININ HA1 SUBUNIT, HEMAGGLUTININ HA2 SUBUNIT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhu, X., Wilson, I.A.
Deposit date:2018-11-21
Release date:2019-06-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.
Cell Rep, 27, 2019
5BXZ
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H17 BAT INFLUENZA NS1 RNA BINDING DOMAIN
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Hale, B.G.
Deposit date:2015-06-09
Release date:2015-08-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89, 2015
5BY1
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H18 BAT INFLUENZA NS1 RNA BINDING DOMAIN
Descriptor:Non-structural protein 1, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL
Authors:Kerry, P.S., Hale, B.G.
Deposit date:2015-06-09
Release date:2015-08-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89, 2015
5JRZ
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STRUCTURE OF THE NS3 HELICASE FROM THE FRENCH POLYNESIA STRAIN OF THE ZIKA VIRUS
Descriptor:Helicase, ACETATE ION, PYROPHOSPHATE 2-
Authors:Jain, R., Coloma, J., Aggarwal, A.K.
Deposit date:2016-05-06
Release date:2016-07-06
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure of the NS3 helicase from Zika virus.
Nat.Struct.Mol.Biol., 23, 2016
5KQR
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STRUCTURE OF NS5 METHYLTRANSFERASE FROM ZIKA VIRUS BOUND TO S-ADENOSYLMETHIONINE
Descriptor:Methyltransferase, S-ADENOSYLMETHIONINE, PHOSPHATE ION, ...
Authors:Jain, R., Coloma, J., Rajashankar, K.R., Aggarwal, A.K.
Deposit date:2016-07-06
Release date:2016-09-14
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (1.331 Å)
Cite:Structures of NS5 Methyltransferase from Zika Virus.
Cell Rep, 16, 2016
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PDB entries from 2020-11-25