Author results

2I6L
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CRYSTAL STRUCTURE OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE 6 (MAPK6)
Descriptor:Mitogen-activated protein kinase 6
Authors:Filippakopoulos, P., Turnbull, A.P., Savitsky, P., Fedorov, O., Berridge, G., Das, S., Elkins, J., Soundararajan, M., Yang, X.W., Doyle, D., Papagrigoriou, E., Pike, A.C.W., Bunkonczi, G., Ugochukwu, E., Debreczeni, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-08-29
Release date:2006-09-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of the Human Mitogen Activated Protein Kinase 6
To be Published
2JK9
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THE STRUCTURE OF SPLA-RYANODINE RECEPTOR DOMAIN AND SOCS BOX CONTAINING 1 IN COMPLEX WITH A PAR-4 PEPTIDE
Descriptor:SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1, PRKC APOPTOSIS WT1 REGULATOR PROTEIN
Authors:Filippakopoulos, P., Bullock, A., Keates, T., Savitsky, P., Murray, J.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S.
Deposit date:2008-08-22
Release date:2008-09-16
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis for Par-4 Recognition by the Spry Domain-and Socs Box-Containing Proteins Spsb1, Spsb2, and Spsb4.
J.Mol.Biol., 401, 2010
2O2V
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CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE KINASE 5 PHOX DOMAIN (MAP2K5-PHOX) WITH HUMAN MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3 (MAP3K3B-PHOX)
Descriptor:Dual specificity mitogen-activated protein kinase kinase 5, Mitogen-activated protein kinase kinase kinase 3
Authors:Filippakopoulos, P., Savitsky, P., Ugochukwu, E., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-30
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)
To be Published
3BHH
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CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE IIB ISOFORM 1 (CAMK2B)
Descriptor:Calcium/calmodulin-dependent protein kinase type II beta chain, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Authors:Filippakopoulos, P., Rellos, P., Niesen, F., Burgess, N., Bullock, A., Berridge, G., Pike, A.C.W., Ugochukwu, E., Pilka, E.S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-28
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Calcium/Calmodulin-Dependent Protein Kinase IIB Isoform 1 (CAMK2B).
To be Published
3BQR
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CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND
Descriptor:Death-associated protein kinase 3, 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid, S-1,2-PROPANEDIOL, ...
Authors:Filippakopoulos, P., Rellos, P., Fedorov, O., Niesen, F., Pike, A.C.W., Pilka, E.S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-12-20
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Human Death Associated Protein Kinase 3 (DAPK3) in Complex with an Imidazo-Pyridazine Ligand.
To be Published
3EMW
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CRYSTAL STRUCTURE OF HUMAN SPLA/RYANODINE RECEPTOR DOMAIN AND SOCS BOX CONTAINING 2 (SPSB2) IN COMPLEX WITH A 20-RESIDUE VASA PEPTIDE
Descriptor:SPRY domain-containing SOCS box protein 2, Peptide (VASA), 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Sharpe, T., Keates, T., Murray, J.W., Savitsky, P., Roos, A.K., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2008-09-25
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
3F2O
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CRYSTAL STRUCTURE OF HUMAN SPLA/RYANODINE RECEPTOR DOMAIN AND SOCS BOX CONTAINING 1 (SPSB1) IN COMPLEX WITH A 20-RESIDUE VASA PEPTIDE
Descriptor:SPRY domain-containing SOCS box protein 1, 20-mer peptide from ATP-dependent RNA helicase vasa
Authors:Filippakopoulos, P., Sharpe, T., Keates, T., Murray, J.W., Savitsky, P., Roos, A., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2008-10-30
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
3FME
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CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (MEK6) ACTIVATED MUTANT (S207D, T211D)
Descriptor:Dual specificity mitogen-activated protein kinase kinase 6, STAUROSPORINE
Authors:Filippakopoulos, P., Barr, A., Pike, A.C.W., Berridge, G., Elkins, J., Fedorov, O., Keates, T., Savitsky, P., Soundararajan, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-12-21
Release date:2009-01-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D)
To be Published
3KVW
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CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITH AN INDIRUBIN LIGAND
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 2, (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION
Authors:Filippakopoulos, P., Myrianthopoulos, V., Kritsanida, M., Magiatis, P., Skaltsounis, A.L., Soundararajan, M., Krojer, T., Gileadi, O., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
To be Published
4NR4
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH AN ISOXAZOLYL-BENZIMIDAZOLE LIGAND
Descriptor:CREB-binding protein, 1-(4-chlorobenzyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-benzimidazole, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Hay, D., Fedorov, O., Martin, S., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-11-26
Release date:2013-12-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
TO BE PUBLISHED
4NR5
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH AN ISOXAZOLYL-BENZIMIDAZOLE LIGAND
Descriptor:CREB-binding protein, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, NITRATE ION, ...
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Hay, D., Fedorov, O., Martin, S., Pike, A.W., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-11-26
Release date:2013-12-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
To be Published
4NR6
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH AN OXAZEPIN LIGAND
Descriptor:CREB-binding protein, 1-[7-(3,4-dimethoxyphenyl)-9-{[(3R)-1-methylpiperidin-3-yl]methoxy}-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]propan-1-one
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Hay, D., Fedorov, O., Martin, S., Chaikuad, A., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-11-26
Release date:2013-12-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand
To be Published
4NR7
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH AN ISOXAZOLYL-BENZIMIDAZOLE LIGAND
Descriptor:CREB-binding protein, 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Hay, D., Fedorov, O., Martin, S., Krojer, T., Nowak, R., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-11-26
Release date:2013-12-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
To be Published
4NR8
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH AN ISOXAZOLYL-BENZIMIDAZOLE LIGAND
Descriptor:Bromodomain-containing protein 4, POTASSIUM ION, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, ...
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Hay, D., Fedorov, O., Martin, S., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-11-26
Release date:2013-12-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.635 Å)
Cite:Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand
To be Published
4NYV
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH A QUINAZOLIN-ONE LIGAND
Descriptor:CREB-binding protein, 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., Martin, S., Monteiro, O.P., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-12-11
Release date:2014-01-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand
TO BE PUBLISHED
4NYW
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH A DIHYDROQUINOXALINONE LIGAND
Descriptor:CREB-binding protein, THIOCYANATE ION, (3R)-N-[3-(3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide, ...
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Rooney, T.P.C., Fedorov, O., Martin, S., Monteiro, O.P., Conway, S.J., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-12-11
Release date:2014-01-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
TO BE PUBLISHED
4NYX
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP IN COMPLEX WITH A DIHYDROQUINOXALINONE LIGAND
Descriptor:CREB-binding protein, (3R)-N-[3-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide
Authors:Filippakopoulos, P., Picaud, S., Felletar, I., Rooney, T.P.C., Fedorov, O., Martin, S., Monteiro, O.P., Conway, S.J., von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-12-11
Release date:2014-01-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
TO BE PUBLISHED
2OSS
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 1 IN HUMAN BROMODOMAIN CONTAINING PROTEIN 4 (BRD4)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Keates, T., Savitsky, P., Burgess, N., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-02-06
Release date:2007-02-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2OUO
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 2 IN HUMAN BROMODOMAIN CONTAINING PROTEIN 4 (BRD4)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Keates, T., Savitsky, P., Burgess, N., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2RFJ
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 1 IN HUMAN BROMODOMAIN CONTAINING PROTEIN, TESTIS SPECIFIC (BRDT)
Descriptor:Bromodomain testis-specific protein
Authors:Filippakopoulos, P., Salah, E., Savitsky, P., Keates, T., Parizotto, E., Elkins, J., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-09-30
Release date:2007-10-23
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3BKB
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CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES)
Descriptor:Proto-oncogene tyrosine-protein kinase Fes/Fps, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Salah, E., Fedorov, O., Cooper, C., Ugochukwu, E., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-12-06
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
3CBL
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CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE
Descriptor:Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, STAUROSPORINE
Authors:Filippakopoulos, P., Salah, E., Cooper, C., Picaud, S.S., Elkins, J.M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-22
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
3CD3
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CRYSTAL STRUCTURE OF PHOSPHORYLATED HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE
Descriptor:Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, CHLORIDE ION, ...
Authors:Filippakopoulos, P., Salah, E., Cooper, C., Picaud, S.S., Elkins, J.M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-26
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
3MQM
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN ASH1L
Descriptor:Probable histone-lysine N-methyltransferase ASH1L
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Vollmar, M., Chaikuad, A., Krojer, T., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-04-28
Release date:2010-05-19
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
1Z83
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CRYSTAL STRUCTURE OF HUMAN AK1A IN COMPLEX WITH AP5A
Descriptor:Adenylate kinase 1, ZINC ION, SULFATE ION, ...
Authors:Filippakopoulos, P., Bunkoczi, G., Jansson, A., Schreurs, A., Knapp, S., Edwards, A., von Delft, F., Sundstrom, M., Structural Genomics Consortium (SGC)
Deposit date:2005-03-29
Release date:2005-04-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human AK1A in complex with AP5A
To be Published