Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

Summary for 3CBL

DescriptorProto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, STAUROSPORINE, ... (4 entities in total)
Functional Keywordsfes, v-fes, fujinami, avian sarcoma, viral, oncogene, feline sarcoma virus, sgc, structural genomics consortium, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight44807.37
Primary citation
Filippakopoulos, P.,Kofler, M.,Hantschel, O.,Gish, G.D.,Grebien, F.,Salah, E.,Neudecker, P.,Kay, L.E.,Turk, B.E.,Superti-Furga, G.,Pawson, T.,Knapp, S.
Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134:793-803, 2008
PubMed: 18775312 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2008.07.047
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23250.3%0.7%36.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report