3CBL
Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE STU A 901 |
| Chain | Residue |
| A | ILE567 |
| A | LEU690 |
| A | SER700 |
| A | ASP701 |
| A | GLY568 |
| A | ARG569 |
| A | ALA588 |
| A | GLU607 |
| A | GLU637 |
| A | LEU638 |
| A | GLY642 |
| A | ARG687 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE STU A 902 |
| Chain | Residue |
| A | ASP583 |
| A | THR585 |
| A | ARG621 |
| A | LEU622 |
| A | ILE623 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE STU A 903 |
| Chain | Residue |
| A | HIS456 |
| A | LYS553 |
| A | TRP554 |
| A | GLU559 |
| A | ARG581 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGNFGEVFsGrlradntl..........VAVK |
| Chain | Residue | Details |
| A | ILE567-LYS590 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNCLV |
| Chain | Residue | Details |
| A | CYS679-VAL691 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"15485904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18046454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18775312","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19382747","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7687763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ARG687 | |
| A | ASP683 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP683 | |
| A | ALA685 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP683 | |
| A | ALA685 | |
| A | ASN688 |
