5E7D

Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand

Summary for 5E7D

• Entry DOI: 10.2210/pdb5e7d/pdb
• Descriptor: Protein polybromo-1, (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, chemical probe, ligand, inhibitor, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q86U86
• Total number of polymer chains: 4
• Total formula weight: 59418.97

Authors

Filippakopoulos, P.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Owen, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-10-12, release date: 2016-10-12)

• Primary citation: Filippakopoulos, P.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Owen, D.,Knapp, S.; Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.87 Å)