5E7D
Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0016586 | cellular_component | RSC-type complex |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0016586 | cellular_component | RSC-type complex |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0016586 | cellular_component | RSC-type complex |
| D | 0006338 | biological_process | chromatin remodeling |
| D | 0016586 | cellular_component | RSC-type complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 5KL A 801 |
| Chain | Residue |
| A | ILE651 |
| A | LEU655 |
| A | TYR664 |
| A | MET672 |
| A | ASN702 |
| A | ALA703 |
| A | ASN707 |
| A | ILE713 |
| D | EDO802 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue 5KL B 801 |
| Chain | Residue |
| B | ILE651 |
| B | PHE652 |
| B | LEU655 |
| B | LEU661 |
| B | TYR664 |
| B | MET672 |
| B | ALA703 |
| B | ASN707 |
| B | ILE713 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 5KL C 801 |
| Chain | Residue |
| C | ILE651 |
| C | PHE652 |
| C | LEU655 |
| C | TYR664 |
| C | MET672 |
| C | ALA703 |
| C | ASN707 |
| C | ILE713 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 5KL D 801 |
| Chain | Residue |
| D | ILE651 |
| D | PHE652 |
| D | LEU655 |
| D | TYR664 |
| D | MET672 |
| D | ALA703 |
| D | ASN707 |
| D | ILE713 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 802 |
| Chain | Residue |
| A | 5KL801 |
| D | ILE651 |
| D | ILE713 |
| D | ASP716 |
| D | HOH923 |
| D | HOH926 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY |
| Chain | Residue | Details |
| A | SER649-TYR706 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Domain: {"description":"Bromo 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
