3CY3

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V

Summary for 3CY3

• Entry DOI: 10.2210/pdb3cy3/pdb
• Related: 3CXW 3CY2
• Descriptor: Serine/threonine-protein kinase pim-1, Pimtide peptide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 2
• Total formula weight: 37827.02

Authors

Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-04-25, release date: 2008-07-15, Last modification date: 2023-08-30)

• Primary citation: Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)