3CY3
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase pim-1 | polymer | 314 | 35799.7 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (human) | |
| 2 | B | Pimtide peptide | polymer | 14 | 1592.8 | 1 | synthetic construct | ||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | A | (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile | non-polymer | 372.4 | 1 | Chemie (JN5) | |||
| 5 | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Gly 250 | Arg 250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37392.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 434.5 | |
| All* | Total formula weight | 37827.0 |
