Author results

2WU6
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CRYSTAL STRUCTURE OF THE HUMAN CLK3 IN COMPLEX WITH DKI
分子名称:DUAL SPECIFICITY PROTEIN KINASE CLK3, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, SULFATE ION, ...
著者Muniz, J.R.C., Fedorov, O., King, O., Filippakopoulos, P., Bullock, A.N., Philips, C., Heightman, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
登録日2009-09-30
公開日2009-10-20
最終更新日2011-12-07
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18, 2011
2WU7
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CRYSTAL STRUCTURE OF THE HUMAN CLK3 IN COMPLEX WITH V25
分子名称:DUAL SPECIFICITY PROTEIN KINASE CLK3, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, SULFATE ION, ...
著者Muniz, J.R.C., Fedorov, O., King, O., Filippakopoulos, P., Bullock, A.N., Phillips, C., Heightman, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Bracher, F., Huber, K., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
登録日2009-09-30
公開日2009-10-20
最終更新日2011-12-07
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18, 2011
2VAG
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CRYSTAL STRUCTURE OF DI-PHOSPHORYLATED HUMAN CLK1 IN COMPLEX WITH A NOVEL SUBSTITUTED INDOLE INHIBITOR
分子名称:DUAL SPECIFICITY PROTEIN KINASE CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
著者Pike, A.C.W., Bullock, A.N., Fedorov, O., Pilka, E.S., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Huber, K., Bracher, F., Knapp, S.
登録日2007-08-31
公開日2007-10-09
最終更新日2011-12-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18, 2011
2C2H
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CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP
分子名称:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
著者Debreczeni, J.E., Yang, X., Zao, Y., Elkins, J., Gileadi, C., Burgess, N., Colebrook, S., Gileadi, O., Fedorov, O., Bunkoczi, G., von Delft, F., Doyle, D., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
登録日2005-09-29
公開日2005-10-13
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of the Human Rac3 in Complex with Gdp
To be Published
2CHL
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STRUCTURE OF CASEIN KINASE 1 GAMMA 3
分子名称:CASEIN KINASE I ISOFORM GAMMA-3, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, SULFATE ION
著者Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Ugochukwu, E., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-03-15
公開日2006-03-22
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of Casein Kinase 1 Gamma 3
To be Published
2G0N
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THE CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP AND CHLORIDE
分子名称:Ras-related C3 botulinum toxin substrate 3, MAGNESIUM ION, CHLORIDE ION, ...
著者Ugochukwu, E., Yang, X., Zao, Y., Elkins, J., Gileadi, C., Burgess, N., Colebrook, S., Gileadi, O., Fedorov, O., Bunkoczi, G., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-02-13
公開日2006-05-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Crystal Structure of the Human RAC3 in complex with GDP and Chloride
To be Published
2GF0
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THE CRYSTAL STRUCTURE OF THE HUMAN DIRAS1 GTPASE IN THE INACTIVE GDP BOUND STATE
分子名称:GTP-binding protein Di-Ras1, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Turnbull, A.P., Papagrigoriou, E., Yang, X., Schoch, G., Elkins, J., Gileadi, O., Salah, E., Bray, J., Wen-Hwa, L., Fedorov, O., Niesen, F.E., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-03-21
公開日2006-04-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state
To be Published
2IZR
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
分子名称:CASEIN KINASE I ISOFORM GAMMA-3, {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE, MAGNESIUM ION, ...
著者Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-07-26
公開日2006-08-01
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Inhibitor Binding by Casein Kinases
To be Published
2IZS
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
分子名称:CASEIN KINASE I ISOFORM GAMMA-3, {[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE, MAGNESIUM ION, ...
著者Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-07-26
公開日2006-08-01
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Inhibitor Binding by Casein Kinases
To be Published
2IZT
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
分子名称:CASEIN KINASE I ISOFORM GAMMA-3, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE, CHLORIDE ION
著者Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-07-26
公開日2006-08-01
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibitor Binding by Casein Kinases
To be Published
2IZU
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
分子名称:CASEIN KINASE I ISOFORM GAMMA-3, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, 1,2-ETHANEDIOL, ...
著者Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
登録日2006-07-26
公開日2006-08-01
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Inhibitor Binding by Casein Kinases
To be Published
2JC6
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE 1D
分子名称:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1D, N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE
著者Debreczeni, J.E., Rellos, P., Fedorov, O., Niesen, F.H., Bhatia, C., Shrestha, L., Salah, E., Smee, C., Colebrook, S., Berridge, G., Gileadi, O., Bunkoczi, G., Ugochukwu, E., Pike, A.C.W., von Delft, F., Knapp, S., Sundstrom, M., Weigelt, J., Arrowsmith, C.H., Edwards, A.
登録日2006-12-19
公開日2007-02-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of Human Calmodulin-Dependent Protein Kinase 1D
To be Published
2OZF
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THE CRYSTAL STRUCTURE OF THE 2ND PDZ DOMAIN OF THE HUMAN NHERF-1 (SLC9A3R1)
分子名称:Ezrin-radixin-moesin-binding phosphoprotein 50
著者Phillips, C., Papagrigoriou, E., Gileadi, C., Fedorov, O., Elkins, J., Berridge, G., Turnbull, A.P., Gileadi, O., Schoch, G., Smee, C., Bray, J., Savitsky, P., Uppenberg, J., von Delft, F., Gorrec, F., Umeano, C., Salah, E., Colebrook, S., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2007-02-26
公開日2007-03-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The crystal structure of the 2nd PDZ domain of the human NHERF-1 (SLC9A3R1)
To be Published
2Q3H
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THE CRYSTAL STRUCTURE OF RHOUA IN THE GDP-BOUND STATE.
分子名称:Ras homolog gene family, member U, MAGNESIUM ION, ...
著者Gileadi, C., Yang, X., Papagrigoriou, E., Elkins, J., Zhao, Y., Bray, J., Gileadi, O., Umeano, C., Ugochukwu, E., Uppenberg, J., Bunkoczi, G., von Delft, F., Pike, A.C.W., Phillips, C., Savitsky, P., Fedorov, O., Edwards, A., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2007-05-30
公開日2007-06-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献The crystal structure of RhouA in the GDP-bound state.
To be Published
2W4O
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CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITH 4-AMINO(SULFAMOYL- PHENYLAMINO)-TRIAZOLE-CARBOTHIOIC ACID (2,6-DIFLUORO-PHENYL)-AMIDE)
分子名称:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
著者Muniz, J.R.C., Rellos, P., Gileadi, O., Fedorov, O., Filippakopoulos, P., Salah, E., Pike, A., Phillips, C., Niesen, F., Shrestha, L., Burgess-Brown, N., Bullock, A., Berridge, G., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Knapp, S.
登録日2008-11-28
公開日2009-01-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Crystal Structure of Human Camk4 in Complex with 4-Amino(Sulfamoyl-Phenylamino)-Triazole- Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
To be Published
2WEI
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF CRYPTOSPORIDIUM PARVUM CALCIUM DEPENDENT PROTEIN KINASE IN COMPLEX WITH 3-MB-PP1
分子名称:CALMODULIN-DOMAIN PROTEIN KINASE 1, PUTATIVE, 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
著者Roos, A.K., King, O., Chaikuad, A., Zhang, C., Shokat, K.M., Wernimont, A.K., Artz, J.D., Lin, L., MacKenzie, F.I., Finerty, P.J., Vedadi, M., Schapira, M., Indarte, M., Kozieradzki, I., Pike, A.C.W., Fedorov, O., Doyle, D., Muniz, J., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Heightman, T., Hui, R.
登録日2009-03-31
公開日2009-04-28
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The Cryptosporidium Parvum Kinome.
Bmc Genomics, 12, 2011
2X4F
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THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAIN KINASE LOC340156.
分子名称:MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4, 4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amine, SULFATE ION, ...
著者Muniz, J.R.C., Mahajan, P., Rellos, P., Fedorov, O., Shrestha, B., Wang, J., Elkins, J.M., Daga, N., Cocking, R., Chaikuad, A., Krojer, T., Ugochukwu, E., Yue, W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Gileadi, O., Knapp, S.
登録日2010-01-29
公開日2010-02-09
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156
To be Published
2X7F
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- AND NCK- INTERACTING KINASE WITH WEE1CHK1 INHIBITOR
分子名称:TRAF2 AND NCK-INTERACTING PROTEIN KINASE, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, SODIUM ION
著者Vollmar, M., Alfano, I., Shrestha, B., Bray, J., Muniz, J.R.C., Roos, A., Filippakopoulos, P., Burgess-Brown, N., Ugochukwu, E., Gileadi, O., Phillips, C., Mahajan, P., Pike, A.C.W., Fedorov, O., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
登録日2010-02-26
公開日2010-07-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor
To be Published
2X7G
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STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN-SPECIFIC KINASE 2 (SRPK2) BOUND TO PURVALANOL B
分子名称:UNCHARACTERIZED PROTEIN SRPK2, PURVALANOL B, SULFATE ION, ...
著者Pike, A.C.W., Savitsky, P., Fedorov, O., Krojer, T., Ugochukwu, E., von Delft, F., Gileadi, O., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S.
登録日2010-02-26
公開日2010-04-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (Srpk2) Bound to Purvalanol B
To be Published
3KVW
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CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITH AN INDIRUBIN LIGAND
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 2, (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION
著者Filippakopoulos, P., Myrianthopoulos, V., Kritsanida, M., Magiatis, P., Skaltsounis, A.L., Soundararajan, M., Krojer, T., Gileadi, O., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S., Structural Genomics Consortium (SGC)
登録日2009-11-30
公開日2010-01-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
To be Published
3OOM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00507
分子名称:Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ...
著者Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-08-31
公開日2010-10-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
3RAW
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CRYSTAL STRUCTURE OF HUMAN CDC-LIKE KINASE 3 ISOFORM IN COMPLEX WITH LEUCETTINE L41
分子名称:Dual specificity protein kinase CLK3, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one
著者Filippakopoulos, P., Fedorov, O., King, O., Debdab, M., Carreaux, F., Renault, S., Bullock, A., Muniz, J.R.C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Meijer, L., Bazureau, J.P., Knapp, S., Structural Genomics Consortium (SGC)
登録日2011-03-28
公開日2011-05-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal Structure of human CDC-like kinase 3 isoform with a benzo-dioxol ligand
To be Published
3S95
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CRYSTAL STRUCTURE OF THE HUMAN LIMK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
分子名称:LIM domain kinase 1, STAUROSPORINE, SODIUM ION, ...
著者Beltrami, A., Chaikuad, A., Daga, N., Elkins, J.M., Mahajan, P., Savitsky, P., Vollmar, M., Krojer, T., Muniz, J.R.C., Fedorov, O., Allerston, C.K., Yue, W.W., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
登録日2011-05-31
公開日2011-07-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
To be Published
4DYM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00135
分子名称:Activin receptor type-1, SULFATE ION, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ...
著者Chaikuad, A., Sanvitale, C., Cooper, C., Canning, P., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Krojer, T., Filippakopoulos, P., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
登録日2012-02-29
公開日2012-03-21
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
To be Published
4O38
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CRYSTAL STRUCTURE OF THE HUMAN CYCLIN G ASSOCIATED KINASE (GAK)
分子名称:Cyclin-G-associated kinase, SUCCINIC ACID, GLYCEROL
著者Zhang, R., Hatzos-Skintges, C., Weger, A., Chaikuad, A., Eswaran, J., Fedorov, O., King, O., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structural Genomics Consortium (SGC)
登録日2013-12-18
公開日2014-01-01
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Crystal structure of the human cyclin G associated kinase (GAK)
To be Published