5N2L

Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue

Summary for 5N2L

• Entry DOI: 10.2210/pdb5n2l/pdb
• Descriptor: Bromodomain-containing protein 2, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: transcription, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 56020.31

Authors

Tallant, C.,Slavish, P.J.,Siejka, P.,Bharatham, N.,Shadrick, W.R.,Chai, S.,Young, B.M.,Boyd, V.A.,Heroven, C.,Wiggers, H.J.,Picaud, S.,Fedorov, O.,Krojer, T.,Chen, T.,Lee, R.E.,Guy, R.K.,Shelat, A.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-02-07, release date: 2018-02-28, Last modification date: 2024-01-17)

• Primary citation: Tallant, C.,Slavish, P.J.,Siejka, P.,Bharatham, N.,Shadrick, W.R.,Chai, S.,Young, B.M.,Boyd, V.A.,Heroven, C.,Wiggers, H.J.,Picaud, S.,Fedorov, O.,Krojer, T.,Chen, T.,Lee, R.E.,Guy, R.K.,Shelat, A.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.89 Å)